Quantifying 3D Strain in Scaffold Implants for Regenerative Medicine.
X-ray computed tomography
biomaterials
cartilage regeneration
digital volume correlation
in situ mechanics
micro-CT
tissue regeneration
Journal
Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929
Informations de publication
Date de publication:
03 Sep 2020
03 Sep 2020
Historique:
received:
29
07
2020
revised:
27
08
2020
accepted:
01
09
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
10
9
2020
Statut:
epublish
Résumé
Regenerative medicine solutions require thoughtful design to elicit the intended biological response. This includes the biomechanical stimulus to generate an appropriate strain in the scaffold and surrounding tissue to drive cell lineage to the desired tissue. To provide appropriate strain on a local level, new generations of scaffolds often involve anisotropic spatially graded mechanical properties that cannot be characterised with traditional materials testing equipment. Volumetric examination is possible with three-dimensional (3D) imaging, in situ loading and digital volume correlation (DVC). Micro-CT and DVC were utilised in this study on two sizes of 3D-printed inorganic/organic hybrid scaffolds (
Identifiants
pubmed: 32899192
pii: ma13173890
doi: 10.3390/ma13173890
pmc: PMC7504351
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Department of Health
ID : NIHR300013
Pays : United Kingdom
Organisme : Engineering and Physical Sciences Research Council
ID : EP/N025059/1
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