The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation.
Drosophila
TORC1
TORC2
ageing
autophagy
metabolism
nutrient-response
transcription
translation
yeast
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
03 09 2020
03 09 2020
Historique:
received:
18
08
2020
revised:
28
08
2020
accepted:
30
08
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
1
4
2021
Statut:
epublish
Résumé
Ageing is a complex trait controlled by genes and the environment. The highly conserved mechanistic target of rapamycin signalling pathway (mTOR) is a major regulator of lifespan in all eukaryotes and is thought to be mediating some of the effects of dietary restriction. mTOR is a rheostat of energy sensing diverse inputs such as amino acids, oxygen, hormones, and stress and regulates lifespan by tuning cellular functions such as gene expression, ribosome biogenesis, proteostasis, and mitochondrial metabolism. Deregulation of the mTOR signalling pathway is implicated in multiple age-related diseases such as cancer, neurodegeneration, and auto-immunity. In this review, we briefly summarise some of the workings of mTOR in lifespan and ageing through the processes of transcription, translation, autophagy, and metabolism. A good understanding of the pathway's outputs and connectivity is paramount towards our ability for genetic and pharmacological interventions for healthy ageing and amelioration of age-related disease.
Identifiants
pubmed: 32899412
pii: genes11091043
doi: 10.3390/genes11091043
pmc: PMC7565554
pii:
doi:
Substances chimiques
TOR Serine-Threonine Kinases
EC 2.7.11.1
Sirolimus
W36ZG6FT64
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MR/M02492X/1
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C416/A25145
Pays : United Kingdom
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