The Role of Epac in Cancer Progression.
Epac
PKA
cAMP
cancer
reactive oxygen species (ROS)
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
05 Sep 2020
05 Sep 2020
Historique:
received:
30
06
2020
revised:
28
07
2020
accepted:
29
07
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
25
2
2021
Statut:
epublish
Résumé
Cancer continues to be a prime contributor to global mortality. Despite tremendous research efforts and major advances in cancer therapy, much remains to be learned about the underlying molecular mechanisms of this debilitating disease. A better understanding of the key signaling events driving the malignant phenotype of cancer cells may help identify new pharmaco-targets. Cyclic adenosine 3',5'-monophosphate (cAMP) modulates a plethora of biological processes, including those that are characteristic of malignant cells. Over the years, most cAMP-mediated actions were attributed to the activity of its effector protein kinase A (PKA). However, studies have revealed an important role for the exchange protein activated by cAMP (Epac) as another effector mediating the actions of cAMP. In cancer, Epac appears to have a dual role in regulating cellular processes that are essential for carcinogenesis. In addition, the development of Epac modulators offered new routes to further explore the role of this cAMP effector and its downstream pathways in cancer. In this review, the potentials of Epac as an attractive target in the fight against cancer are depicted. Additionally, the role of Epac in cancer progression, namely its effect on cancer cell proliferation, migration/metastasis, and apoptosis, with the possible interaction of reactive oxygen species (ROS) in these phenomena, is discussed with emphasis on the underlying mechanisms and pathways.
Identifiants
pubmed: 32899451
pii: ijms21186489
doi: 10.3390/ijms21186489
pmc: PMC7555121
pii:
doi:
Substances chimiques
Guanine Nucleotide Exchange Factors
0
RAPGEF3 protein, human
0
Cyclic AMP
E0399OZS9N
Cyclic AMP-Dependent Protein Kinases
EC 2.7.11.11
rap1 GTP-Binding Proteins
EC 3.6.5.2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : American University of Beirut
ID : MPP 320133
Organisme : University of Petra
ID : 5/4/2020
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