Metabolic Potential of Cancer Cells in Context of the Metastatic Cascade.
ROS
RedOx balance
bioenergetics
biosynthesis
cancer metabolism
hypoxia
metabolic plasticity
metastasis
one-carbon metabolism
tumour microenvironment
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
05 09 2020
05 09 2020
Historique:
received:
07
08
2020
revised:
01
09
2020
accepted:
02
09
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
28
4
2021
Statut:
epublish
Résumé
The metastatic cascade is a highly plastic and dynamic process dominated by cellular heterogeneity and varying metabolic requirements. During this cascade, the three major metabolic pillars, namely biosynthesis, RedOx balance, and bioenergetics, have variable importance. Biosynthesis has superior significance during the proliferation-dominated steps of primary tumour growth and secondary macrometastasis formation and only minor relevance during the growth-independent processes of invasion and dissemination. Consequently, RedOx homeostasis and bioenergetics emerge as conceivable metabolic key determinants in cancer cells that disseminate from the primary tumour. Within this review, we summarise our current understanding on how cancer cells adjust their metabolism in the context of different microenvironments along the metastatic cascade. With the example of one-carbon metabolism, we establish a conceptual view on how the same metabolic pathway can be exploited in different ways depending on the current cellular needs during metastatic progression.
Identifiants
pubmed: 32899554
pii: cells9092035
doi: 10.3390/cells9092035
pmc: PMC7563895
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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