Development and Long-Term Follow-Up of an Experimental Model of Myocardial Infarction in Rabbits.
cardiac mapping
experimental surgery
ischemia/reperfusion injury
myocardial infarction
ventricular arrhythmias
ventricular remodeling
Journal
Animals : an open access journal from MDPI
ISSN: 2076-2615
Titre abrégé: Animals (Basel)
Pays: Switzerland
ID NLM: 101635614
Informations de publication
Date de publication:
04 Sep 2020
04 Sep 2020
Historique:
received:
14
07
2020
revised:
21
08
2020
accepted:
01
09
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
10
9
2020
Statut:
epublish
Résumé
A chronic model of acute myocardial infarction was developed to study the mechanisms involved in adverse postinfarction ventricular remodeling. In an acute myocardial infarction (AMI), the left circumflex coronary artery of New Zealand White rabbits (n = 9) was occluded by ligature for 1 h, followed by reperfusion. A specific care protocol was applied before, during, and after the intervention, and the results were compared with those of a sham operated group (n = 7). After 5 weeks, programmed stimulation and high-resolution mapping were performed on isolated and perfused hearts using the Langendorff technique. The infarct size determined by 2,3,5-triphenyltetrazolium chloride inside of the area at risk (thioflavin-S) was then determined. The area at risk was similar in both groups (54.33% (experimental infarct group) vs. 58.59% (sham group), ns). The infarct size was 73.16% as a percentage of the risk area. The experimental infarct group had a higher inducibility of ventricular arrhythmias (100% vs. 43% in the sham group,
Identifiants
pubmed: 32899601
pii: ani10091576
doi: 10.3390/ani10091576
pmc: PMC7552163
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Generalitat Valenciana
ID : PROMETEO/2018/078
Organisme : Instituto de Salud Carlos III
ID : CB16/11/00486
Organisme : Instituto de Salud Carlos III
ID : PI15/01408
Organisme : Instituto de Salud Carlos III
ID : PIE15/00013
Organisme : Instituto de Salud Carlos III
ID : PI18/01620
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