Metabolic Characterization and Consequences of Mitochondrial Pyruvate Carrier Deficiency in
drosophila
kinetics
metabolomics
mitochondrial pyruvate carrier
mitochondrial respiration
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
06 Sep 2020
06 Sep 2020
Historique:
received:
20
07
2020
revised:
24
08
2020
accepted:
03
09
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
10
9
2020
Statut:
epublish
Résumé
In insect, pyruvate is generally the predominant oxidative substrate for mitochondria. This metabolite is transported inside mitochondria via the mitochondrial pyruvate carrier (MPC), but whether and how this transporter controls mitochondrial oxidative capacities in insects is still relatively unknown. Here, we characterize the importance of pyruvate transport as a metabolic control point for mitochondrial substrate oxidation in two genotypes of an insect model,
Identifiants
pubmed: 32899962
pii: metabo10090363
doi: 10.3390/metabo10090363
pmc: PMC7570025
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : RGPIN-2017-05100
Organisme : New Brunswick Innovation Foundation
ID : NA
Organisme : Université de Moncton
ID : NA
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