Targeting chromatin dysregulation in organ fibrosis.
Chromatin remodeling
DNA methylation
Epigenetics
Extracellular matrix
Fibrosis
Histone modifications
Journal
Cytokine & growth factor reviews
ISSN: 1879-0305
Titre abrégé: Cytokine Growth Factor Rev
Pays: England
ID NLM: 9612306
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
29
07
2020
revised:
24
08
2020
accepted:
25
08
2020
pubmed:
10
9
2020
medline:
25
9
2021
entrez:
9
9
2020
Statut:
ppublish
Résumé
Fibrosis leads to destruction of organ architecture accompanied by chronic inflammation and loss of function. Fibrosis affects nearly every organ in the body and accounts for ∼45% of total deaths worldwide. Over the past decade, tremendous progress has been made in understanding the basic mechanisms leading to organ fibrosis. However, we are limited with therapeutic options and there is a significant need to develop highly effective anti-fibrotic therapies. Recent advances in sequencing technologies have advanced the burgeoning field of epigenetics towards molecular understanding at a higher resolution. Here we provide a comprehensive review of the recent advances in chromatin regulatory processes, specifically DNA methylation, post-translational modification of histones, and chromatin remodeling complexes in kidney, liver and lung fibrosis. Although this research field is young, we discuss new strategies for potential therapeutic interventions for treating organ fibrosis.
Identifiants
pubmed: 32900600
pii: S1359-6101(20)30203-3
doi: 10.1016/j.cytogfr.2020.08.004
pii:
doi:
Substances chimiques
Chromatin
0
Histones
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
64-72Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.