Bowel contrast-enhanced ultrasound perfusion imaging in the evaluation of Crohn's disease patients undergoing anti-TNFα therapy.

Adult Crohn Disease / diagnostic imaging Female Humans Infliximab Male Middle Aged Perfusion Imaging / methods Prospective Studies Tumor Necrosis Factor Inhibitors Ultrasonography / methods
Crohn Dynamic CEUS Endoscopic remission IBD Response to therapy

Journal

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
ISSN: 1878-3562
Titre abrégé: Dig Liver Dis
Pays: Netherlands
ID NLM: 100958385

Informations de publication

Date de publication:
06 2021
Historique:
received: 16 03 2020
revised: 01 07 2020
accepted: 02 08 2020
pubmed: 10 9 2020
medline: 1 2 2022
entrez: 9 9 2020
Statut: ppublish

Résumé

To evaluate whether changes in bowel perfusion parameters measured by dynamic-CEUS (D-CEUS) can be used for monitoring response to therapy in active Crohn disease (CD). Fifty-four CD patients were evaluated with d-CEUS before (T0) and after 2 (T1), 6 (T2) and 12 weeks (T3) of anti-TNFα therapy. Variations from baseline were calculated for: peak intensity, PI; area under the curve, AUC; slope of wash in, P 70% of patients achieved combined endoscopic/clinical response (responders). The reduction in PI, AUC, P d-CEUS might become a reliable predictor of combined endoscopic/clinical response and clinical relapse in CD.

Identifiants

DOI: 10.1016/j.dld.2020.08.005 PMID: 32900648
pubmed: 32900648
pii: S1590-8658(20)30399-6
doi: 10.1016/j.dld.2020.08.005
pii:
doi:

Substances chimiques

Tumor Necrosis Factor Inhibitors 0
Infliximab B72HH48FLU

Types de publication

Journal Article Observational Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

729-737

Informations de copyright

Copyright © 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest No potential conflicts of interest. No financial support.

Auteurs

Lucrezia Laterza (L)

Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University, Rome, Italy.

Maria Elena Ainora (ME)

Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University, Rome, Italy. Electronic address: ainoramariaelena@gmail.com.

Matteo Garcovich (M)

Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University, Rome, Italy.

Linda Galasso (L)

Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University, Rome, Italy.

Andrea Poscia (A)

Catholic University, Rome, Italy.

Enrico Di Stasio (E)

Department of Biochemistry and Clinical Biochemistry, Fondazione PoliclinicoUniversitario A. Gemelli IRCCS, Catholic University of Rome, Italy.

Andrea Lupascu (A)

Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University, Rome, Italy.

Laura Riccardi (L)

Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University, Rome, Italy.

Franco Scaldaferri (F)

Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University, Rome, Italy.

Alessandro Armuzzi (A)

Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University, Rome, Italy.

Gian Ludovico Rapaccini (GL)

Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University, Rome, Italy.

Antonio Gasbarrini (A)

Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University, Rome, Italy.

Maurizio Pompili (M)

Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University, Rome, Italy.

Maria Assunta Zocco (MA)

Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University, Rome, Italy.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Bowel contrast-enhanced ultrasound perfusion...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › Maladie de Crohn › Bowel contrast-enhanced ultrasound perfusion...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Bowel contrast-enhanced ultrasound perfusion...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Infliximab › Bowel contrast-enhanced ultrasound perfusion...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Bowel contrast-enhanced ultrasound perfusion...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Imagerie de perfusion › Bowel contrast-enhanced ultrasound perfusion...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Bowel contrast-enhanced ultrasound perfusion...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Inhibiteurs du facteur de nécrose tumorale › Bowel contrast-enhanced ultrasound perfusion...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Échographie › Bowel contrast-enhanced ultrasound perfusion...