Multiplexed chemogenetics in astrocytes and motoneurons restore blood-spinal cord barrier in ALS.
Amyotrophic Lateral Sclerosis
/ blood
Animals
Astrocytes
/ metabolism
Disease Models, Animal
Disease Progression
Female
Humans
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Motor Neurons
/ metabolism
Spinal Cord
/ metabolism
Spine
/ blood supply
Superoxide Dismutase
/ metabolism
Superoxide Dismutase-1
/ genetics
Wnt Proteins
/ metabolism
Wnt-5a Protein
/ metabolism
Journal
Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
03
10
2019
revised:
24
08
2020
accepted:
31
08
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
17
7
2021
Statut:
epublish
Résumé
Blood-spinal cord barrier (BSCB) disruption is thought to contribute to motoneuron (MN) loss in amyotrophic lateral sclerosis (ALS). It is currently unclear whether impairment of the BSCB is the cause or consequence of MN dysfunction and whether its restoration may be directly beneficial. We revealed that
Identifiants
pubmed: 32900826
pii: 3/11/e201900571
doi: 10.26508/lsa.201900571
pmc: PMC7479971
pii:
doi:
Substances chimiques
Wnt Proteins
0
Wnt-5a Protein
0
Wnt5a protein, mouse
0
Wnt7a protein, mouse
0
Superoxide Dismutase
EC 1.15.1.1
Superoxide Dismutase-1
EC 1.15.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2020 Ouali Alami et al.
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