Is type 2 diabetes mellitus an inverse risk factor for the development of rheumatoid arthritis?
Journal
Journal of human genetics
ISSN: 1435-232X
Titre abrégé: J Hum Genet
Pays: England
ID NLM: 9808008
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
02
06
2020
accepted:
31
08
2020
revised:
30
08
2020
pubmed:
10
9
2020
medline:
29
6
2021
entrez:
9
9
2020
Statut:
ppublish
Résumé
Type 2 diabetes mellitus (T2DM) and rheumatoid arthritis (RA) are both chronic diseases. Although the link between metabolic abnormalities and dysregulated inflammation has received much attention, it is not known whether T2DM can be a risk for the development of RA. Also, observational studies have the disadvantage that the possibility of confounding factors, such as environmental factors, cannot be ruled out. Therefore, the current study performed the mendelian randomization (MR) analysis using recent large-scale genome-wide association studies datasets of T2DM and RA separately European and Asian ancestries. As a result, T2DM had an inverse causal effect on the risk of RA. This study proposed a novel hypothesis that a protective effect of T2DM for the risk of RA.
Identifiants
pubmed: 32901113
doi: 10.1038/s10038-020-00837-2
pii: 10.1038/s10038-020-00837-2
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
219-223Références
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