Mechanisms of bone development and repair.
Journal
Nature reviews. Molecular cell biology
ISSN: 1471-0080
Titre abrégé: Nat Rev Mol Cell Biol
Pays: England
ID NLM: 100962782
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
accepted:
23
07
2020
pubmed:
10
9
2020
medline:
15
12
2020
entrez:
9
9
2020
Statut:
ppublish
Résumé
Bone development occurs through a series of synchronous events that result in the formation of the body scaffold. The repair potential of bone and its surrounding microenvironment - including inflammatory, endothelial and Schwann cells - persists throughout adulthood, enabling restoration of tissue to its homeostatic functional state. The isolation of a single skeletal stem cell population through cell surface markers and the development of single-cell technologies are enabling precise elucidation of cellular activity and fate during bone repair by providing key insights into the mechanisms that maintain and regenerate bone during homeostasis and repair. Increased understanding of bone development, as well as normal and aberrant bone repair, has important therapeutic implications for the treatment of bone disease and ageing-related degeneration.
Identifiants
pubmed: 32901139
doi: 10.1038/s41580-020-00279-w
pii: 10.1038/s41580-020-00279-w
pmc: PMC7699981
mid: NIHMS1641529
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
696-711Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE026730
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE027323
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM119995
Pays : United States
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