Peritoneal carcinomatosis in gastric cancer: Are Hispanics at higher risk?
Adenocarcinoma
/ epidemiology
Adult
Black or African American
/ statistics & numerical data
Aged
California
/ epidemiology
Female
Follow-Up Studies
Hispanic or Latino
/ statistics & numerical data
Humans
Incidence
Male
Middle Aged
Peritoneal Neoplasms
/ epidemiology
Prognosis
Registries
Risk Factors
Stomach Neoplasms
/ epidemiology
White People
/ statistics & numerical data
Young Adult
Hispanic
epidemiology
gastric cancer
peritoneal carcinomatosis
Journal
Journal of surgical oncology
ISSN: 1096-9098
Titre abrégé: J Surg Oncol
Pays: United States
ID NLM: 0222643
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
10
06
2020
revised:
27
07
2020
accepted:
24
08
2020
pubmed:
10
9
2020
medline:
5
1
2021
entrez:
9
9
2020
Statut:
ppublish
Résumé
A recent study from our group identified Hispanic race/ethnicity as an independent predictor of peritoneal carcinomatosis (PC) in gastric cancer. We sought to identify the tumor factors that might contribute to this strong association in Hispanics. California Cancer Registry data were used to identify patients diagnosed with gastric adenocarcinoma from 2004 to 2014. Logistic regression analyses were performed to determine odds ratios for cancer stage, tumor location, grade, histology, and PC. Of 16,275 patients with gastric adenocarcinoma who met inclusion criteria, 6463 (39.7%) were non-Hispanic White (NHW), 4953 (30.4%) were Hispanic, 1020 (6.3%) were non-Hispanic Black (NHB), and 3915 (23.6%) were Asian/other. Compared to NHW, Hispanics were more likely to have a poorly differentiated grade (65.9% vs. 57.6%; p < .001), signet ring adenocarcinoma (28.1% vs. 17.6%; p < .001) and stage IV (51.9% vs. 45.0%; p < .001) gastric cancer. The proportion of stage IV patients with PC was also significantly higher in Hispanics compared to NHW, NHB, and Asian/other (28.5% vs. 16.6%, 20.5%, and 25.2%, respectively; p < .001). Hispanic ethnicity is an independent predictor of aggressive tumor phenotype and PC. Disproportionate incidence of signet ring adenocarcinoma and PC highlight the need to explore the genomic differences in Hispanic gastric cancer.
Sections du résumé
BACKGROUND
BACKGROUND
A recent study from our group identified Hispanic race/ethnicity as an independent predictor of peritoneal carcinomatosis (PC) in gastric cancer. We sought to identify the tumor factors that might contribute to this strong association in Hispanics.
METHODS
METHODS
California Cancer Registry data were used to identify patients diagnosed with gastric adenocarcinoma from 2004 to 2014. Logistic regression analyses were performed to determine odds ratios for cancer stage, tumor location, grade, histology, and PC.
RESULTS
RESULTS
Of 16,275 patients with gastric adenocarcinoma who met inclusion criteria, 6463 (39.7%) were non-Hispanic White (NHW), 4953 (30.4%) were Hispanic, 1020 (6.3%) were non-Hispanic Black (NHB), and 3915 (23.6%) were Asian/other. Compared to NHW, Hispanics were more likely to have a poorly differentiated grade (65.9% vs. 57.6%; p < .001), signet ring adenocarcinoma (28.1% vs. 17.6%; p < .001) and stage IV (51.9% vs. 45.0%; p < .001) gastric cancer. The proportion of stage IV patients with PC was also significantly higher in Hispanics compared to NHW, NHB, and Asian/other (28.5% vs. 16.6%, 20.5%, and 25.2%, respectively; p < .001).
CONCLUSIONS
CONCLUSIONS
Hispanic ethnicity is an independent predictor of aggressive tumor phenotype and PC. Disproportionate incidence of signet ring adenocarcinoma and PC highlight the need to explore the genomic differences in Hispanic gastric cancer.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1624-1629Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
Miller KD, Goding Sauer A, Ortiz AP, et al. Cancer statistics for Hispanics/Latinos, 2018. CA Cancer J Clin. 2018;68(6):425-445.
Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62(1):10-29.
Haile RW, John EM, Levine AJ, et al. A review of cancer in U.S. Hispanic populations. Cancer Prev Res. 2012;5(2):150-163.
Singh GK, Jemal A. Socioeconomic and racial/ethnic disparities in cancer mortality, incidence, and survival in the United States, 1950-2014: over six decades of changing patterns and widening inequalities. J Environ Public Health. 2017:2819372.
Ji L, Selleck MJ, Morgan JW, et al. Gastric cancer peritoneal carcinomatosis risk score. Ann Surg Oncol. 2019.
California Cancer Registry (CCR). https://www.ccrcal.org/learn-about-ccr/. Accessed May 7, 2020
Yost K, Perkins C, Cohen R, Morris C, Wright W. Socioeconomic status and breast cancer incidence in California for different race/ethnic groups. Cancer Causes Control. 2001;12(8):703-711.
Fritz A, Percy C, Jack A, et al. International Classification of Diseases for Oncology. 3rd ed. Geneva, Switzerland: World Health Organization; 2000.
SAS/STAT, SAS/STAT 14.1 User′s Guide. Cary, NC: SAS Institute Inc.
Statistical RRAlaef. R Foundation for Statistical Computing, wR-poAO, Vienna, Austria, 2018.
Merchant SJ, Kim J, Choi AH, Sun V, Chao J, Nelson R. A rising trend in the incidence of advanced gastric cancer in young Hispanic men. Gastric Cancer. 2017;20(2):226-234.
Balakrishnan M, George R, Sharma A, Graham DY, Malaty HM. An Investigation into the recent increase in gastric cancer in the USA. Dig Dis Sci. 2018;63(6):1613-1619.
Spolverato G, Ejaz A, Kim Y, et al. Rates and patterns of recurrence after curative intent resection for gastric cancer: a United States multi-institutional analysis. J Am Coll Surg. 2014;219(4):664-675.
Li, C, Kim, S, Lai JF, et al. Advanced gastric carcinoma with signet ring cell histology. Oncology. 2007;72(1-2):64-68.
Yao, JC, Tseng, JF, Worah S, et al. Clinicopathologic behavior of gastric adenocarcinoma in Hispanic patients: analysis of a single institution's experience over 15 years. J Clin Oncol. 2005;23(13):3094-3103.
Long Parma, D, Muñoz, E, Ogden SM, et al. Helicobacter pylori infection in Texas Hispanic and Non-Hispanic White men: implications for gastric cancer risk disparities. Am J Mens Health. 2017;11(4):1039-1045.
Rubicz, R, Leach, CT, Kraig E, et al. Seroprevalence of 13 common pathogens in a rapidly growing U.S. minority population: Mexican Americans from San Antonio, TX. BMC Res Notes. 2011;4:433.
Loh, JT, Shaffer, CL, Piazuelo MB, et al. Analysis of CagA in Helicobacter pylori strains from Colombian populations with contrasting gastric cancer risk reveals a biomarker for disease severity. Cancer Epidemiol Biomarkers Prev. 2011;20(10):2237-2249.
Jang, S, Su, H, Blum FC, et al. Dynamic expansion and contraction of CagA copy number in Helicobacter pylori impact development of gastric disease. mBio. 2017;8:1.
Blaser MJ, Perez-Perez GI, Kleanthous H, et al. Infection with Helicobacter pylori strains possessing CagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res. 1995;55(10):2111-2115.
D'Angelica M, Gonen M, Brennan MF, Turnbull AD, Bains M, Karpeh MS. Patterns of initial recurrence in completely resected gastric adenocarcinoma. Ann Surg. 2004;240(5):808-816.
Parsonnet J, Replogle M, Yang S, Hiatt R. Seroprevalence of CagA-positive strains among Helicobacter pylori-infected, healthy young adults. J Infect Dis. 1997;175(5):1240-1242.
USCBAFFUSCB. https://www.factfinder.census.gov/faces/nav/jsf/pages/index.xhtml. Accessed May 7, 2020.
Sierra MS, Cueva P, Bravo LE, Forman D. Stomach cancer burden in Central and South America. Cancer Epidemiol. 2016;44(suppl 1):S62-S73.
Bonequi P, Meneses-Gonzalez F, Correa P, Rabkin CS, Camargo MC. Risk factors for gastric cancer in Latin America: a meta-analysis. Cancer Causes Control. 2013;24(2):217-231.
Chang, ET, Gomez, SL, Fish K., et al. Gastric cancer incidence among Hispanics in California: patterns by time, nativity, and neighborhood characteristics. Cancer Epidemiol Biomarkers Prev. 2012;21(5):709-719.
Sanjeevaiah A, Cheedella N, Hester C, Porembka MR. Gastric cancer: recent molecular classification advances, racial disparity, and management implications. J Oncol Pract. 2018;14(4):217-224.
Sun Y, Gu J, Ajani JA, Chang DW, Wu X, Stroehlein JR. Genetic and intermediate phenotypic susceptibility markers of gastric cancer in Hispanic Americans: a case-control study. Cancer. 2014;120(19):3040-3048.
Martinez Tyson D, Medina-Ramirez P, Flores AM, Siegel R, Aguado Loi C. Unpacking Hispanic ethnicity-cancer mortality differentials among Hispanic subgroups in the United States, 2004-2014. Front Public Health. 2018;6:219.