Biodegradable Metal-Organic Framework-Based Microrobots (MOFBOTs).
biodegradation
drug delivery
metal-organic frameworks
microrobots
zeolitic imidazolate frameworks
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
18
06
2020
revised:
14
08
2020
pubmed:
10
9
2020
medline:
15
5
2021
entrez:
9
9
2020
Statut:
ppublish
Résumé
Microrobots and metal-organic frameworks (MOFs) have been identified as promising carriers for drug delivery applications. While clinical applications of microrobots are limited by their low drug loading efficiencies and the poor degradability of the materials used for their fabrication, MOFs lack motility and targeted drug delivery capabilities. The combination of these two fields marks the beginning of a new era; MOF-based small-scale robots (MOFBOTs) for biomedical applications. Yet, biodegradability is a major hurdle in the field of micro- and nanoswimmers including small-scale robots. Here, a highly integrated MOFBOT that is able to realize magnetic locomotion, drug delivery, and selective degradation in cell cultures is reported for the first time. The MOF used in the investigations does not only allow a superior loading of chemotherapeutic drugs and their controlled release via a pH-responsive degradation but it also enables the controlled locomotion of enzymatically biodegradable gelatin-based helical microrobots under magnetic fields. The degradation of the integrated MOFBOT is observed after two weeks, when all its components fully degrade. Additionally, drug delivery studies performed in cancer cell cultures show reduced viability upon delivery of Doxorubicin within short time frames. This MOFBOT system opens new avenues for highly integrated fully biodegradable small-scale robots.
Identifiants
pubmed: 32902185
doi: 10.1002/adhm.202001031
doi:
Substances chimiques
Metal-Organic Frameworks
0
Doxorubicin
80168379AG
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2001031Informations de copyright
© 2020 Wiley-VCH GmbH.
Références
a) W. Hu, G. Z. Lum, M. Mastrangeli, M. Sitti, Nature 2018, 554, 81;
b) X. Z. Chen, B. Jang, D. Ahmed, C. Hu, C. de Marco, M. Hoop, F. Mushtaq, B. J. Nelson, S. Pane, Adv. Mater. 2018, 30, 1705061;
c) J. J. Abbott, Z. Nagy, F. Beyeler, B. J. Nelson, IEEE Robot. Autom. Mag. 2007, 14, 92.
a) H. Ceylan, J. Giltinan, K. Kozielski, M. Sitti, Lab Chip 2017, 17, 1705;
b) M. Sitti, H. Ceylan, W. Hu, J. Giltinan, M. Turan, S. Yim, E. Diller, Proc. IEEE Inst. Elecr. Electron. Eng. 2015, 103, 205;
c) X. Hu, B. Lim, S. R. Torati, J. Ding, V. Novosad, M.-Y. Im, V. Reddy, K. Kim, E. Jung, A. I. Shawl, E. Kim, C. Kim, Small 2018, 14, 1800504.
a) S. Palagi, A. G. Mark, S. Y. Reigh, K. Melde, T. Qiu, H. Zeng, C. Parmeggiani, D. Martella, A. Sanchez-Castillo, N. Kapernaum, F. Giesselmann, D. S. Wiersma, E. Lauga, P. Fischer, Nat. Mater. 2016, 15, 647;
b) H.-W. Huang, M. S. Sakar, A. J. Petruska, S. Pané, B. J. Nelson, Nat. Commun. 2016, 7, 12263;
c) H. Shum, Micromachines (Basel) 2019, 10, 65.
a) M. Sitti, D. S. Wiersma, Adv. Mater. 2020, 32, 1906766;
b) P. Erkoc, I. C. Yasa, H. Ceylan, O. Yasa, Y. Alapan, M. Sitti, Adv. Ther. 2019, 2, 1800064;
c) A. Aghakhani, O. Yasa, P. Wrede, M. Sitti, Proc. Natl. Acad. Sci. U. S. A. 2020, 117, 3469.
a) C. Chautems, B. Zeydan, S. Charreyron, G. Chatzipirpiridis, S. Pané, B. J. Nelson, Eur. J. Cardiothorac. Surg. 2017, 51, 405;
b) B. Wang, Y. Zhang, L. Zhang, Quant. Imaging Med. Surg. 2018, 8, 461.
a) P. TirgarBahnamiri, S. Bagheri-Khoulenjani, Med. Hypotheses 2017, 102, 56;
b) K. E. Peyer, L. Zhang, B. J. Nelson, Nanoscale 2013, 5, 1259;
c) J. Park, C. Jin, S. Lee, J.-Y. Kim, H. Choi, Adv. Healthcare Mater. 2019, 8, 1900213.
M. Sitti, Nat. Rev. Mater. 2018, 3, 74.
A. Terzopoulou, M. Hoop, X.-Z. Chen, A. M. Hirt, M. Charilaou, Y. Shen, F. Mushtaq, A. P. del Pino, C. Logofatu, L. Simonelli, A. J. de Mello, C. J. Doonan, J. Sort, B. J. Nelson, S. Pané, J. Puigmartí-Luis, Angew. Chem., Int. Ed. 2019, 58, 13550.
a) H. Furukawa, K. E. Cordova, M. O'Keeffe, O. M. Yaghi, Science 2013, 341, 1230444;
b) P. Horcajada, T. Chalati, C. Serre, B. Gillet, C. Sebrie, T. Baati, J. F. Eubank, D. Heurtaux, P. Clayette, C. Kreuz, J.-S. Chang, Y. K. Hwang, V. Marsaud, P.-N. Bories, L. Cynober, S. Gil, G. Férey, P. Couvreur, R. Gref, Nat. Mater. 2010, 9, 172;
c) N. Stock, S. Biswas, Chem. Rev. 2012, 112, 933.
a) P. Horcajada, R. Gref, T. Baati, P. K. Allan, G. Maurin, P. Couvreur, G. Férey, R. E. Morris, C. Serre, Chem. Rev. 2012, 112, 1232;
b) S. Keskin, S. Kızılel, Ind. Eng. Chem. Res. 2011, 50, 1799;
c) M.-X. Wu, Y.-W. Yang, Adv. Mater. 2017, 29, 1606134;
d) K. Lu, T. Aung, N. Guo, R. Weichselbaum, W. Lin, Adv. Mater. 2018, 30, 1707634.
a) X.-G. Wang, Z.-Y. Dong, H. Cheng, S.-S. Wan, W.-H. Chen, M.-Z. Zou, J.-W. Huo, H.-X. Deng, X.-Z. Zhang, Nanoscale 2015, 7, 16061;
b) Q. Wu, M. Li, L. Tan, J. Yu, Z. Chen, L. Su, X. Ren, C. Fu, J. Ren, L. Li, F. Cao, P. Liang, Y. Zhang, X. Meng, Nanoscale Horiz. 2018, 3, 606;
c) L. Gao, Q. Chen, T. Gong, J. Liu, C. Li, Nanoscale 2019, 11, 21030;
d) D. Wang, J. Zhou, R. Shi, H. Wu, R. Chen, B. Duan, G. Xia, P. Xu, H. Wang, S. Zhou, C. Wang, H. Wang, Z. Guo, Q. Chen, Theranostics 2017, 7, 4605.
B. Khezri, M. Pumera, Adv. Mater. 2019, 31, 1806530.
a) R. Ricco, L. Malfatti, M. Takahashi, A. J. Hill, P. Falcaro, J. Mater. Chem. A 2013, 1, 13033;
b) J. Aguilera-Sigalat, D. Bradshaw, Coord. Chem. Rev. 2016, 307, 267;
c) X. Wang, X.-Z. Chen, C. C. J. Alcântara, S. Sevim, M. Hoop, A. Terzopoulou, C. de Marco, C. Hu, A. J. de Mello, P. Falcaro, S. Furukawa, B. J. Nelson, J. Puigmartí-Luis, S. Pané, Adv. Mater. 2019, 31, 1901592.
M. Jian, B. Liu, R. Liu, J. Qu, H. Wang, X. Zhang, RSC Adv. 2015, 5, 48433.
A. Barla, J. Nicolas, D. Cocco, S. M. Valvidares, J. Herrero-Martin, P. Gargiani, J. Moldes, C. Ruget, E. Pellegrin, S. Ferrer, J. Synchrotron. Radiat. 2016, 23, 1507.
a) J. P. Singh, B. Kaur, A. Sharma, S. H. Kim, S. Gautam, R. C. Srivastava, N. Goyal, W. C. Lim, H. J. Lin, J. M. Chen, K. Asokan, D. Kanjilal, S. O. Won, I.-J. Lee, K. H. Chae, Phys. Chem. Chem. Phys. 2018, 20, 12084;
b) D. H. Kim, H. J. Lee, G. Kim, Y. S. Koo, J. H. Jung, H. J. Shin, J. Y. Kim, J. S. Kang, Phys. Rev. B 2009, 79, 033402.
I. Brigger, C. Dubernet, P. Couvreur, Adv. Drug Delivery Rev. 2002, 54, 631.
M. Hoop, C. F. Walde, R. Riccò, F. Mushtaq, A. Terzopoulou, X.-Z. Chen, A. J. deMello, C. J. Doonan, P. Falcaro, B. J. Nelson, J. Puigmartí-Luis, S. Pané, Appl. Mater. Today 2018, 11, 13.
L. Gu, R. H. Fang, M. J. Sailor, J.-H. Park, ACS Nano 2012, 6, 4947.
X. Wang, X.-H. Qin, C. Hu, A. Terzopoulou, X.-Z. Chen, T.-Y. Huang, K. Maniura-Weber, S. Pané, B. J. Nelson, Adv. Funct. Mater. 2018, 28, 1804107.
F. Qiu, B. J. Nelson, Engineering 2015, 1, 021.