Minimally dependent activity subspaces for working memory and motor preparation in the lateral prefrontal cortex.
lateral prefrontal cortex
motor preparation
neuroscience
rhesus macaque
working memory
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
09 09 2020
09 09 2020
Historique:
received:
22
04
2020
accepted:
21
08
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
25
2
2021
Statut:
epublish
Résumé
The lateral prefrontal cortex is involved in the integration of multiple types of information, including working memory and motor preparation. However, it is not known how downstream regions can extract one type of information without interference from the others present in the network. Here, we show that the lateral prefrontal cortex of non-human primates contains two minimally dependent low-dimensional subspaces: one that encodes working memory information, and another that encodes motor preparation information. These subspaces capture all the information about the target in the delay periods, and the information in both subspaces is reduced in error trials. A single population of neurons with mixed selectivity forms both subspaces, but the information is kept largely independent from each other. A bump attractor model with divisive normalization replicates the properties of the neural data. These results provide new insights into neural processing in prefrontal regions.
Identifiants
pubmed: 32902383
doi: 10.7554/eLife.58154
pii: 58154
pmc: PMC7481007
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education - Singapore
ID : MOE2016-T2-2-117
Pays : International
Organisme : Ministry of Education - Singapore
ID : MOE2017-T3-1-002
Pays : International
Informations de copyright
© 2020, Tang et al.
Déclaration de conflit d'intérêts
CT, RH, AP, CL, SY No competing interests declared
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