Adduct of the blistering warfare agent sesquimustard with human serum albumin and its mass spectrometric identification for biomedical verification of exposure.
Hydroxyethylthioethyl
Protein adduct
Sulfur mustard
Verification
Vesicant
Journal
Analytical and bioanalytical chemistry
ISSN: 1618-2650
Titre abrégé: Anal Bioanal Chem
Pays: Germany
ID NLM: 101134327
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
10
07
2020
accepted:
25
08
2020
revised:
07
08
2020
pubmed:
10
9
2020
medline:
21
5
2021
entrez:
9
9
2020
Statut:
ppublish
Résumé
Apart from the well-known sulfur mustard (SM), additional sulfur-containing blistering chemical warfare agents exist. Sesquimustard (Q) is one of them and five times more blistering than SM. It is a common impurity in mustard mixtures and regularly found in old munitions but can also be used in pure form. Compared to the extensive literature on SM, very little experimental data is available on Q and no protein biomarkers of exposure have been reported. We herein report for the first time the adduct of Q with the nucleophilic Cys
Identifiants
pubmed: 32902690
doi: 10.1007/s00216-020-02917-w
pii: 10.1007/s00216-020-02917-w
pmc: PMC7550388
doi:
Substances chimiques
Biomarkers
0
Chemical Warfare Agents
0
Mustard Compounds
0
Serum Albumin, Human
ZIF514RVZR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7723-7737Références
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