Disparity in the effect of morphine on eupnea and gasping in anesthetized spontaneously breathing adult rats.
autoresuscitation
eupnea
gasping
opioids
respiratory depression
Journal
American journal of physiology. Regulatory, integrative and comparative physiology
ISSN: 1522-1490
Titre abrégé: Am J Physiol Regul Integr Comp Physiol
Pays: United States
ID NLM: 100901230
Informations de publication
Date de publication:
01 11 2020
01 11 2020
Historique:
pubmed:
10
9
2020
medline:
17
12
2020
entrez:
9
9
2020
Statut:
ppublish
Résumé
The goal of this study was to examine the effects of systemic morphine on the pattern and morphology of gasping breathing during respiratory autoresuscitation from transient anoxia. We hypothesized that systemic morphine levels sufficient to cause significant depression of eupnea would also cause depression of gasping breathing. Respiratory and cardiovascular variables were studied in 20 spontaneously breathing pentobarbital-anaesthetized adult male rats. Sham (saline) injections caused no significant change in resting respiratory or cardiovascular variables (
Identifiants
pubmed: 32903040
doi: 10.1152/ajpregu.00031.2020
doi:
Substances chimiques
Analgesics, Opioid
0
Hypnotics and Sedatives
0
Morphine
76I7G6D29C
Pentobarbital
I4744080IR
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM