Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension.
Animals
Benzamides
/ pharmacology
Heart
/ drug effects
Hydrogen Peroxide
/ pharmacology
Hypertension
/ metabolism
Imidazoles
/ pharmacology
MAP Kinase Kinase Kinase 5
/ metabolism
Myocardium
/ metabolism
Myocytes, Cardiac
/ drug effects
Oxidation-Reduction
Oxidative Stress
/ drug effects
Protein Kinase Inhibitors
/ pharmacology
Pyridines
/ pharmacology
Rats
Reactive Oxygen Species
/ metabolism
Signal Transduction
/ drug effects
Ventricular Remodeling
/ drug effects
p38 Mitogen-Activated Protein Kinases
/ metabolism
angiotensin
heart disease
hypertension
oxidative stress reactive oxygen species
protein kinase
Journal
Hypertension (Dallas, Tex. : 1979)
ISSN: 1524-4563
Titre abrégé: Hypertension
Pays: United States
ID NLM: 7906255
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
1
5
2021
Statut:
ppublish
Résumé
Systemic hypertension increases cardiac workload causing cardiomyocyte hypertrophy and increased cardiac fibrosis. An underlying feature is increased production of reactive oxygen species. Redox-sensitive ASK1 (apoptosis signal-regulating kinase 1) activates stress-regulated protein kinases (p38-MAPK [mitogen-activated protein kinases] and JNKs [c-Jun N-terminal kinases]) and promotes fibrosis in various tissues. Here, we determined the specificity of ASK1 signaling in the heart, with the hypothesis that ASK1 inhibitors may be used to manage fibrosis in hypertensive heart disease. Using immunoblotting, we established that moderate levels of H
Identifiants
pubmed: 32903101
doi: 10.1161/HYPERTENSIONAHA.119.14556
pmc: PMC7480944
doi:
Substances chimiques
Benzamides
0
Imidazoles
0
Protein Kinase Inhibitors
0
Pyridines
0
Reactive Oxygen Species
0
Hydrogen Peroxide
BBX060AN9V
p38 Mitogen-Activated Protein Kinases
EC 2.7.11.24
MAP Kinase Kinase Kinase 5
EC 2.7.11.25
selonsertib
NS3988A2TC
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1208-1218Subventions
Organisme : British Heart Foundation
ID : PG/13/71/30460
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/15/24/31367
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/15/31/31393
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/18/33/33621
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/17/11/32841
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/19/24/34262
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204809/Z/16/Z
Pays : United Kingdom
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