Evaluation of Risk Factors for Mortality in Febrile Neutropenia.
Adolescent
Adult
Aged
Antifungal Agents
/ therapeutic use
Antineoplastic Agents
/ adverse effects
Case-Control Studies
Febrile Neutropenia
/ microbiology
Female
Hematologic Neoplasms
/ drug therapy
Humans
Invasive Fungal Infections
/ chemically induced
Male
Middle Aged
Retrospective Studies
Risk Factors
Young Adult
Febrile neutropenia
Hematologic malignity
invasive fungal infection
mortality
solid tumor
Journal
Journal of infection in developing countries
ISSN: 1972-2680
Titre abrégé: J Infect Dev Ctries
Pays: Italy
ID NLM: 101305410
Informations de publication
Date de publication:
31 08 2020
31 08 2020
Historique:
received:
06
02
2020
accepted:
08
06
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
24
8
2021
Statut:
epublish
Résumé
We aimed to evaluate the epidemiology of infections and factors associated with mortality in patients with febrile neutropenia (FEN). The adult patients, who developed FEN after chemotherapy due to a hematologic malignancy or a solid tumor in a training and research hospital were evaluated, retrospectively. The demographic data of the patients, underlying malignancy, administered antimicrobial therapy, microbiological findings, and other risk factors associated with mortality were evaluated. A total of 135 FEN episodes of 115 patients, who comprised of 72 (63%) patients with 89 FEN episodes due to hematologic malignancies (hemato-group) and 43 (37%) patients with 46 FEN episodes due to solid organ cancers (onco-group), were evaluated in the study. The median age was 47 years (range: 17-75 years) and 66 (57%) patients were male. A total of 12 patients (8.8%) died during 135 episodes of FEN including nine cases from hemato-group and three cases from onco-group. Those factors including a presence of pneumonia, advanced age, persistent fever despite an antimicrobial treatment, and need for mechanical ventilation in intensive care unit (ICU) with were determined as risk factors associated with mortality. Morbidity and mortality are more common in patients with hematological malignancies compared to patients with solid organ cancers due to prolonged neutropenia. In case of persistent fever, an invasive fungal infection (IFI) should be kept in mind in patients with hematologic malignancies and then antifungal treatment should be initiated. Although a persistent fever is also common in patients with solid tumors, the necessity of antifungal therapy is rare due to the short duration of neutropenia.
Substances chimiques
Antifungal Agents
0
Antineoplastic Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
886-892Informations de copyright
Copyright (c) 2020 Sabahat Ceken, Habip Gedik , Gulsen Iskender, Meryem Demirelli, Duygu Mert, Goknur Yapar Toros, Tugce Nur Yigenoglu, Fevzi Altuntas, Berna Oksuzoglu, Mustafa Ertek.
Déclaration de conflit d'intérêts
No Conflict of Interest is declared