A biomechanical test model for evaluating osseous and osteochondral tissue adhesives.
Biomechanical model
Bone adhesive
Calcium phosphate cements
Fracture repair
Orthobiologics
Phosphoserine
Tissue adhesive
Journal
BMC biomedical engineering
ISSN: 2524-4426
Titre abrégé: BMC Biomed Eng
Pays: England
ID NLM: 101756092
Informations de publication
Date de publication:
2019
2019
Historique:
received:
04
01
2019
accepted:
31
03
2019
entrez:
9
9
2020
pubmed:
7
5
2019
medline:
7
5
2019
Statut:
epublish
Résumé
Currently there are no standard models with which to evaluate the biomechanical performance of calcified tissue adhesives, in vivo Cylindrical cores (diameter (Ø) 2 mm (mm) × 2 mm depth), containing both cancellous and cortical bone, were fractured out from the distal femur and then reattached using one of two tissue adhesives. The adhesiveness of fibrin glue (Tisseel Despite the challenges associated with biomechanical testing in small rodent models the preclinical ex-vivo test model presented herein is both sensitive and accurate. It enabled differences in tissue adhesive strength to be quantified even for very small osseous fragments (<Ø4mm). Importantly, this model can easily be scaled to larger animals and adapted to fracture fragment fixation in human bone. The present model is also compatible with other long-term in vivo evaluation methods (i.e. in vivo imaging, histological analysis, etc.).
Sections du résumé
BACKGROUND
BACKGROUND
Currently there are no standard models with which to evaluate the biomechanical performance of calcified tissue adhesives, in vivo
RESULTS
RESULTS
Cylindrical cores (diameter (Ø) 2 mm (mm) × 2 mm depth), containing both cancellous and cortical bone, were fractured out from the distal femur and then reattached using one of two tissue adhesives. The adhesiveness of fibrin glue (Tisseel
CONCLUSIONS
CONCLUSIONS
Despite the challenges associated with biomechanical testing in small rodent models the preclinical ex-vivo test model presented herein is both sensitive and accurate. It enabled differences in tissue adhesive strength to be quantified even for very small osseous fragments (<Ø4mm). Importantly, this model can easily be scaled to larger animals and adapted to fracture fragment fixation in human bone. The present model is also compatible with other long-term in vivo evaluation methods (i.e. in vivo imaging, histological analysis, etc.).
Identifiants
pubmed: 32903290
doi: 10.1186/s42490-019-0011-2
pii: 11
pmc: PMC7422571
doi:
Types de publication
Journal Article
Langues
eng
Pagination
11Subventions
Organisme : AHRQ HHS
ID : T32 HS000046
Pays : United States
Informations de copyright
© The Author(s) 2019.
Déclaration de conflit d'intérêts
Competing interestsThe following authors declare partial ownership in a company that owns all related intellectual property (GPBio LTD): Michael Pujari-Palmer (M.P.), Gerard Insley (G.I.), Philip Procter (P.P.), Håkan Engqvist (H.E.).
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