ACE2 Expression in the Cat and the Tiger Gastrointestinal Tracts.
COVID-19
SARS-CoV-2
angiotensin-converting enzyme 2
feline
immunohistochemistry
Journal
Frontiers in veterinary science
ISSN: 2297-1769
Titre abrégé: Front Vet Sci
Pays: Switzerland
ID NLM: 101666658
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
05
2020
accepted:
06
07
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
10
9
2020
Statut:
epublish
Résumé
Angiotensin-converting enzyme 2 (ACE2) has been identified as the functional receptor for Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). It has been identified in the human gastrointestinal tract (GIT), and SARS-CoV-2 has been isolated in human and animal fecal samples. The aim of the present study was to investigate the expression of ACE2 in the gastrointestinal tract of domestic (cat) and wild (tiger) felines. Samples of the pylorus, duodenum, and distal colon were collected from six cats and one tiger. The tissues were processed for immunofluorescence assay with an anti-human ACE2 antibody. Angiotensin-converting enzyme 2 was widely expressed in the gastrointestinal mucosa of the cats and the tiger. In both the species, ACE2-immunoreactivity (ACE2-IR) was expressed by the mucosal epithelial cells of the GIT and by the enteric neurons. In the cats, ACE2-IR was also expressed by the smooth muscle cells of the blood vessels and the
Identifiants
pubmed: 32903561
doi: 10.3389/fvets.2020.00514
pmc: PMC7438561
doi:
Types de publication
Journal Article
Langues
eng
Pagination
514Informations de copyright
Copyright © 2020 Chiocchetti, Galiazzo, Fracassi, Giancola and Pietra.
Références
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
J Clin Exp Hepatol. 2020 May-Jun;10(3):263-265
pubmed: 32405183
N Engl J Med. 2020 Aug 6;383(6):592-594
pubmed: 32402157
Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R373-81
pubmed: 16946085
Eur J Neurol. 2020 Apr 25;:
pubmed: 32333487
J Pathol. 2004 Jun;203(2):631-7
pubmed: 15141377
J Med Virol. 2020 Apr 1;:
pubmed: 32239522
Neurogastroenterol Motil. 2017 May;29(5):
pubmed: 27891695
Gastroenterology. 2020 May;158(6):1518-1519
pubmed: 32142785
Science. 2020 May 29;368(6494):1016-1020
pubmed: 32269068
Am J Pathol. 2007 Apr;170(4):1136-47
pubmed: 17392154
Gastroenterology. 2020 May;158(6):1831-1833.e3
pubmed: 32142773
ACS Chem Neurosci. 2020 May 6;11(9):1200-1203
pubmed: 32283006
Vet Pathol. 2008 Jul;45(4):551-62
pubmed: 18587105
Res Vet Sci. 2011 Dec;91(3):e129-35
pubmed: 21349562
Vet Rec. 2020 Apr 18;186(14):457-458
pubmed: 32299985
J Med Virol. 2004 Sep;74(1):1-7
pubmed: 15258961
Vet Microbiol. 2020 May;244:108693
pubmed: 32402329
Microbes Infect. 2020 May - Jun;22(4-5):221-225
pubmed: 32199943
Gastroenterology. 2020 Apr 10;:
pubmed: 32283099
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Eur J Clin Invest. 2020 Sep;50(9):e13276
pubmed: 32406522
Nature. 2012 Jul 25;487(7408):477-81
pubmed: 22837003
J Virol Methods. 2004 Oct;121(1):85-91
pubmed: 15350737
Nat Med. 2020 May;26(5):681-687
pubmed: 32327758
Vet Rec. 2020 Apr 4;186(13):419-420
pubmed: 32245870