Body Surface Mapping of Ventricular Repolarization Heterogeneity: An
T-wave
body surface potential mapping
electrocardiology
sudden cardiac death
ventricular repolarization heterogeneity
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
28
05
2020
accepted:
10
07
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
10
9
2020
Statut:
epublish
Résumé
Increased heterogeneity of ventricular repolarization is associated with life-threatening arrhythmia and sudden cardiac death (SCD). T-wave analysis through body surface potential mapping (BSPM) is a promising tool for risk stratification, but the clinical effectiveness of current electrocardiographic indices is still unclear, with limited experimental validation. This study aims to investigate performance of non-invasive state-of-the-art and novel T-wave markers for repolarization dispersion in an Langendorff-perfused pig hearts ( After drug intervention, both regional and global repolarization heterogeneity were significantly enhanced. On the body surface, T Repolarization heterogeneity significantly affects T-wave properties, and can be non-invasively captured by BSPM-based metrics.
Sections du résumé
BACKGROUND
BACKGROUND
Increased heterogeneity of ventricular repolarization is associated with life-threatening arrhythmia and sudden cardiac death (SCD). T-wave analysis through body surface potential mapping (BSPM) is a promising tool for risk stratification, but the clinical effectiveness of current electrocardiographic indices is still unclear, with limited experimental validation. This study aims to investigate performance of non-invasive state-of-the-art and novel T-wave markers for repolarization dispersion in an
METHODS
METHODS
Langendorff-perfused pig hearts (
RESULTS
RESULTS
After drug intervention, both regional and global repolarization heterogeneity were significantly enhanced. On the body surface, T
CONCLUSION
CONCLUSIONS
Repolarization heterogeneity significantly affects T-wave properties, and can be non-invasively captured by BSPM-based metrics.
Identifiants
pubmed: 32903614
doi: 10.3389/fphys.2020.00933
pmc: PMC7438571
doi:
Types de publication
Journal Article
Langues
eng
Pagination
933Informations de copyright
Copyright © 2020 Meo, Bonizzi, Bear, Cluitmans, Abell, Haïssaguerre, Bernus and Dubois.
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