Estradiol Replacement at the Critical Period Protects Hippocampal Neural Stem Cells to Improve Cognition in APP/PS1 Mice.
Alzheimer’s disease (AD)
estradiol (E2)
hippocampus
neurogenesis
β-amyloid (Aβ)
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2020
2020
Historique:
received:
22
05
2020
accepted:
10
07
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
10
9
2020
Statut:
epublish
Résumé
It has been suggested that there is a critical window for estrogen replacement therapy (ERT) in postmenopausal women with Alzheimer's disease (AD); however, supporting evidence is lacking. To address this issue, we investigated the effective period for estradiol (E2) treatment using a mouse model of AD. Four-month-old female APPswe/PSEN1dE9 (APP/PS1) mice were ovariectomized (OVX) and treated with E2 for 2 months starting at the age of 4 months (early period), 6 months (mid-period), or 8 months (late period). We then evaluated hippocampal neurogenesis, β-amyloid (Aβ) accumulation, telomerase activity, and hippocampal-dependent behavior. Compared to age-matched wild type mice, APP/PS1 mice with intact ovaries showed increased proliferation of hippocampal neural stem cells (NSCs) at 8 months of age and decreased proliferation of NSCs at 10 months of age; meanwhile, Aβ accumulation progressively increased with age, paralleling the reduced survival of immature neurons. OVX-induced depletion of E2 in APP/PS1 mice resulted in elevated Aβ levels accompanied by elevated p75 neurotrophin receptor (p75
Identifiants
pubmed: 32903757
doi: 10.3389/fnagi.2020.00240
pmc: PMC7438824
doi:
Types de publication
Journal Article
Langues
eng
Pagination
240Informations de copyright
Copyright © 2020 Qin, An, Xu, Qi, Wang, Chen, Chen and Sha.
Références
Sci Rep. 2019 Dec 2;9(1):18118
pubmed: 31792359
Brain Struct Funct. 2014 Sep;219(5):1527-41
pubmed: 23716278
Acta Neuropathol. 2017 Feb;133(2):155-175
pubmed: 28025715
Front Mol Neurosci. 2018 May 16;11:160
pubmed: 29867352
Food Funct. 2019 Feb 20;10(2):938-950
pubmed: 30698585
Behav Neurosci. 2018 Aug;132(4):213-223
pubmed: 29952604
Horm Behav. 2018 Jun;102:76-84
pubmed: 29742445
Hippocampus. 2007;17(3):175-80
pubmed: 17286277
JAMA. 2004 Jun 23;291(24):2959-68
pubmed: 15213207
Genes Dev. 2017 Apr 1;31(7):639-647
pubmed: 28428263
Ageing Res Rev. 2014 May;15:1-5
pubmed: 24561251
Elife. 2017 Jan 30;6:
pubmed: 28135190
Mol Neurobiol. 2017 Dec;54(10):7656-7669
pubmed: 27838872
J Alzheimers Dis. 2014;41(1):233-41
pubmed: 24583405
Biochem Biophys Res Commun. 2017 Mar 25;485(1):6-15
pubmed: 28109879
Hippocampus. 2015 Jul;25(7):813-26
pubmed: 25530343
Yonsei Med J. 2005 Aug 31;46(4):471-9
pubmed: 16127770
Glia. 2019 Apr;67(4):688-702
pubmed: 30485550
Neurobiol Aging. 2009 Dec;30(12):1975-85
pubmed: 18374455
Psychoneuroendocrinology. 2009 Jul;34(6):909-16
pubmed: 19216030
Exp Gerontol. 2003 Jan-Feb;38(1-2):53-9
pubmed: 12543261
J Neurobiol. 2005 Nov;65(2):192-204
pubmed: 16118792
Brain Res. 2011 Mar 16;1379:11-22
pubmed: 21241683
Int J Mol Sci. 2018 Sep 27;19(10):
pubmed: 30261693
JAMA. 2002 Nov 6;288(17):2123-9
pubmed: 12413371
Horm Behav. 2014 Sep;66(4):602-18
pubmed: 25205317
Annu Rev Neurosci. 2018 Jul 8;41:431-452
pubmed: 29709208
Nat Neurosci. 2012 Jan 29;15(3):349-57
pubmed: 22286176
Cell. 2016 Nov 3;167(4):897-914
pubmed: 27814520
Learn Mem. 2015 Aug 18;22(9):472-93
pubmed: 26286657
Nat Med. 2007 Apr;13(4):439-47
pubmed: 17351625
Mol Cell Neurosci. 2011 Aug;47(4):306-15
pubmed: 21658451
Curr Alzheimer Res. 2012 Mar;9(3):361-72
pubmed: 22272612
Neurobiol Dis. 2006 Dec;24(3):516-24
pubmed: 17029828
Neurobiol Aging. 2014 Oct;35(10):2183-92
pubmed: 24813636
J Comp Neurol. 2005 Jan 17;481(3):252-65
pubmed: 15593136
J Mol Neurosci. 2002 Aug-Oct;19(1-2):163-6
pubmed: 12212774
Nat Commun. 2019 Mar 13;10(1):1193
pubmed: 30867420
Maturitas. 2016 May;87:5-17
pubmed: 27013283
Mol Neurodegener. 2019 Jun 14;14(1):25
pubmed: 31200742
Neuropharmacology. 2010 Sep-Oct;59(4-5):323-33
pubmed: 20167228
Neurodegener Dis. 2010;7(1-3):163-6
pubmed: 20197698
J Neurosci. 2011 Feb 9;31(6):2292-304
pubmed: 21307265
Front Aging Neurosci. 2019 Sep 06;11:242
pubmed: 31551757
Mol Neurobiol. 2016 Oct;53(8):5796-806
pubmed: 27544234
J Alzheimers Dis. 2002 Dec;4(6):449-57
pubmed: 12515896
Mol Neurobiol. 2016 Jan;53(1):355-368
pubmed: 25432888
J Cereb Blood Flow Metab. 2007 Apr;27(4):669-78
pubmed: 16926839
Stem Cells Int. 2017;2017:6082684
pubmed: 28584529
Neuroreport. 2007 Nov 19;18(17):1801-5
pubmed: 18090315
Mol Neurobiol. 2013 Jun;47(3):857-67
pubmed: 23180279
BMJ. 2019 Mar 6;364:l877
pubmed: 30842090
Hippocampus. 2006;16(3):225-32
pubmed: 16411182
Cereb Cortex. 2017 Mar 1;27(3):2078-2094
pubmed: 26965903
J Am Chem Soc. 2015 Jan 28;137(3):1213-9
pubmed: 25564872
Exp Neurol. 2004 May;187(1):105-17
pubmed: 15081593
J Nucl Med. 2004 Mar;45(3):382-92
pubmed: 15001677
Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13594-9
pubmed: 19633196
J Neurosci. 2007 Nov 28;27(48):13357-65
pubmed: 18045930
Neurology. 2020 Jul 14;95(2):e166-e178
pubmed: 32580974