Reg-1α Promotes Differentiation of Cortical Progenitors via Its N-Terminal Active Domain.
Extl3
GSK-3β
Reg-1α
axon elongation
differentiation
neural progenitors
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
03
2020
accepted:
06
07
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
10
9
2020
Statut:
epublish
Résumé
Reg-1α belongs to the Reg family of small, secreted proteins expressed in both pancreas and nervous system. Reg-1α is composed of two domains, an insoluble C-type lectin domain and a short soluble N-terminal peptide, which is released from the molecule upon proteolytic N-terminal processing, although the biological significance of this proteolysis remains unclear. We have previously shown that binding of Reg-1α to its receptor Extl3 stimulates axonal outgrowth.
Identifiants
pubmed: 32903776
doi: 10.3389/fcell.2020.00681
pmc: PMC7443566
doi:
Types de publication
Journal Article
Langues
eng
Pagination
681Informations de copyright
Copyright © 2020 Varilh, Acquatella-Tran Van Ba, Silhol, Nieto-Lopez, Moussaed, Lebart, Bovolenta, Verdier, Rossel, Marcilhac and Trousse.
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