D-Dimer Concentrations and COVID-19 Severity: A Systematic Review and Meta-Analysis.
COVID-19
D-dimer
SARS-CoV-2
coagulation
thrombosis
Journal
Frontiers in public health
ISSN: 2296-2565
Titre abrégé: Front Public Health
Pays: Switzerland
ID NLM: 101616579
Informations de publication
Date de publication:
2020
2020
Historique:
received:
26
05
2020
accepted:
14
07
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
10
9
2020
Statut:
epublish
Résumé
Coronavirus disease 2019 (COVID-19) is a recently described infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since late 2019, COVID-19 has rapidly spread in virtually all countries, imposing the adoption of significant lockdown and social distancing measures. The activation of the coagulation cascade is a common feature of disseminated intravascular coagulation and adverse clinical outcomes in COVID-19 patients. In this study, we conducted a meta-analysis aiming to investigate differences in serum D-dimer concentrations in patients with and without severe COVID-19 disease. An electronic search in Medline (PubMed), Scopus and Web of Science was performed with no language restrictions, and 13 articles were reporting on 1,807 patients (585, 32.4% with severe disease) were finally identified and included in the meta-analysis. The pooled results of all studies revealed that the D-dimer concentrations were significantly higher in patients with more severe COVID-19 (SMD: 0.91 mg/L; 95% CI, 0.75 to 1.07 mg/L,
Identifiants
pubmed: 32903841
doi: 10.3389/fpubh.2020.00432
pmc: PMC7438945
doi:
Substances chimiques
Fibrin Fibrinogen Degradation Products
0
fibrin fragment D
0
Types de publication
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Pagination
432Informations de copyright
Copyright © 2020 Paliogiannis, Mangoni, Dettori, Nasrallah, Pintus and Zinellu.
Références
Stat Med. 2002 Jun 15;21(11):1539-58
pubmed: 12111919
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
BMC Med Res Methodol. 2011 Apr 07;11:41
pubmed: 21473747
J Med Virol. 2020 Jul;92(7):791-796
pubmed: 32181911
J Gerontol A Biol Sci Med Sci. 2020 Apr 11;:
pubmed: 32279081
BMJ. 2020 Mar 26;368:m1091
pubmed: 32217556
J Autoimmun. 2020 May;109:102433
pubmed: 32113704
J Clin Epidemiol. 2001 Oct;54(10):1046-55
pubmed: 11576817
J Autoimmun. 2020 Jul;111:102452
pubmed: 32291137
Clin Chem Lab Med. 2020 Jun 25;58(7):1116-1120
pubmed: 32172226
J Med Virol. 2020 Jul;92(7):797-806
pubmed: 32198776
BMJ. 2003 Jun 21;326(7403):1358-62
pubmed: 12816821
J Thromb Haemost. 2020 Jun;18(6):1517-1519
pubmed: 32294295
J Clin Invest. 2020 May 1;130(5):2620-2629
pubmed: 32217835
Thromb Haemost. 2020 May;120(5):876-878
pubmed: 32246450
Biometrics. 1994 Dec;50(4):1088-101
pubmed: 7786990
BMC Med Res Methodol. 2014 Dec 19;14:135
pubmed: 25524443
Biometrics. 2000 Jun;56(2):455-63
pubmed: 10877304
J Thromb Haemost. 2020 Apr;18(4):844-847
pubmed: 32073213
Zhonghua Jie He He Hu Xi Za Zhi. 2020 Mar 12;43(3):209-214
pubmed: 32164090
Am J Hematol. 2020 Jul;95(7):834-847
pubmed: 32282949
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Adv Clin Chem. 2015;69:1-46
pubmed: 25934358
Ann Palliat Med. 2020 Mar;9(2):428-436
pubmed: 32233642
Nat Rev Microbiol. 2020 Mar;18(3):123
pubmed: 31988490
J Thromb Haemost. 2020 May;18(5):1094-1099
pubmed: 32220112
J Med Virol. 2020 Apr;92(4):441-447
pubmed: 31994742
JAMA Intern Med. 2020 Jul 1;180(7):934-943
pubmed: 32167524
Allergy. 2020 Jul;75(7):1730-1741
pubmed: 32077115