An Update for the Clinician on Biologics for the Treatment of Psoriatic Arthritis.
JAK-inhibitors
TNF-inhibitors
biological therapies
phosphodiesterase-4
psoriatic arthritis
tofacitinib
tsDMARDs
Journal
Biologics : targets & therapy
ISSN: 1177-5475
Titre abrégé: Biologics
Pays: New Zealand
ID NLM: 101321511
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
04
2020
accepted:
05
08
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
10
9
2020
Statut:
epublish
Résumé
Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy typically associated with psoriasis (PsO). The pathogenesis is strictly related to the association among the presence of genetic risk alleles and innate and acquired immune response with dramatic consequences on bone remodeling. Clinically, PsA patients may present heterogenicity of articular and periarticular manifestations that may be associated with the presence of comorbidities making treatment decision challenging in patients management. The identification of patient-targeted therapies is still a critical issue. Actually, several biological and synthetic drugs are promising in terms of efficacy and safety profile. National and international treatment recommendations support clinicians in the decision of the best treatment, although they may have limits basically related to updates and different outcomes included in the clinical studies evaluated. The aim of this narrative review is therefore to give guidance for clinicians for PsA patients treatment. For this purpose, we evaluated evidence on biological therapies efficacy used for PsA treatment. Specifically, we reviewed data on biological therapies, Janus kinases (JAK) inhibitors, and drugs with a new mechanism of action that are part of the treatment pipeline. The concept of "switching" and "swapping" is also described, as well as data concerning special populations such as pregnant women and elderly patients.
Identifiants
pubmed: 32903867
doi: 10.2147/BTT.S260754
pii: 260754
pmc: PMC7445514
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
53-75Informations de copyright
© 2020 Chimenti et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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