Hypersensitivity to IV Ustekinumab but Tolerance to Subcutaneous Ustekinumab in a Patient With Crohn's Disease.
Journal
ACG case reports journal
ISSN: 2326-3253
Titre abrégé: ACG Case Rep J
Pays: United States
ID NLM: 101638398
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
05
03
2020
accepted:
08
06
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
10
9
2020
Statut:
epublish
Résumé
Ustekinumab is a monoclonal antibody against the p40 subunit of interleukin (IL)-12 and IL-23 and is US Food and Drug Administration (FDA)-approved for plaque psoriasis, moderately to severely active Crohn's disease, and ulcerative colitis. We describe a case of an immediate hypersensitivity reaction to ustekinumab infusion with no reaction to subsequent ustekinumab subcutaneous maintenance therapy. We identify ethylenediaminetetraacetic acid as a unique excipient found in the intravenous formulation compared with the prefilled syringe used for subcutaneous injections, which is likely to account for this observation. No similar cases have been reported in the literature.
Identifiants
pubmed: 32904020
doi: 10.14309/crj.0000000000000449
pii: ACGCR-20-0200
pmc: PMC7449253
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e00449Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK042086
Pays : United States
Informations de copyright
© 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.
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