Type 2 Inflammatory Biomarker Response After Exercise Challenge Testing.
asthma
biomarkers
exercise
inflammation
Journal
Journal of asthma and allergy
ISSN: 1178-6965
Titre abrégé: J Asthma Allergy
Pays: New Zealand
ID NLM: 101543450
Informations de publication
Date de publication:
2020
2020
Historique:
received:
16
04
2020
accepted:
23
06
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
10
9
2020
Statut:
epublish
Résumé
Exercise-induced bronchoconstriction is due to osmotic stimulus of the airway epithelium and leads to a cascade of biomarker release from several inflammatory cells. Several type 2 (T2) mediators have been linked to exercise-induced bronchoconstriction, but the T2 response per se has not been described during exercise. The aim of this study was therefore to investigate T2 biomarkers in plasma and urine from subjects with asthma and healthy controls before and after an exercise challenge. Twenty-two subjects with mild asthma and 18 healthy controls performed an exercise challenge test on a treadmill, and fractional exhaled NO (FeNO) was measured at baseline. Blood and urine samples were collected repeatedly during 60 min after the test and Interleukin-13 (IL-13), thymus and activation-related chemokine (TARC), periostin and leukotrienes were measured. Asthmatics and controls showed similar levels of IL-13, TARC, periostin and Cys-LT in plasma at baseline, and there were no differences in baseline levels between subjects with a negative and positive exercise challenge. After exercise, there was an overall increase in interleukin-13 (IL-13) in plasma in all subjects (p<0.001), with a peak at 10 min after the exercise challenge in both the asthmatic and control group. An increase in TARC in plasma was also seen (p<0.001), but only in the control subjects. In contrast, Cys-LT in plasma showed an overall decrease in all subjects (p<0.001), while periostin in plasma did not change. In conjunction with plasma, the level of IL-13 was increased in urine 30 min after the exercise challenge (p=0.002) and decreased again at 60 min (p=0.004). Similarly, leukotriene E In conclusion, circulating levels of IL-13 are increased after exercise to the same extent in asthmatics and healthy control subjects, which indicates a physiological rather than a pathophysiological response. Also, the levels of TARC and leukotrienes were affected after exercise.
Identifiants
pubmed: 32904520
doi: 10.2147/JAA.S258561
pii: 258561
pmc: PMC7455603
doi:
Types de publication
Journal Article
Langues
eng
Pagination
269-274Informations de copyright
© 2020 Tufvesson et al.
Déclaration de conflit d'intérêts
None of the authors have any conflicts of interest related to the manuscript content.
Références
Pharmacogenet Genomics. 2008 Jul;18(7):551-8
pubmed: 18551035
Respir Med. 2011 Jan;105(1):31-6
pubmed: 20696561
Ann Allergy Asthma Immunol. 2013 Aug;111(2):112-7
pubmed: 23886229
World Allergy Organ J. 2019 Jan 26;12(1):100004
pubmed: 30937129
J Clin Lab Anal. 2018 Feb;32(2):
pubmed: 28493527
Eur Respir J. 1998 Aug;12(2):345-50
pubmed: 9727783
Thorax. 1997 Dec;52(12):1030-5
pubmed: 9516894
Am Rev Respir Dis. 1981 Jun;123(6):659-64
pubmed: 7271065
Ann Allergy Asthma Immunol. 2006 Jun;96(6):819-25
pubmed: 16802769
Chest. 2008 Feb;133(2):404-11
pubmed: 18071011
Am J Respir Cell Mol Biol. 2008 Feb;38(2):153-60
pubmed: 17717322
Immunol Allergy Clin North Am. 2018 May;38(2):165-182
pubmed: 29631728
Allergy. 2018 Jan;73(1):8-16
pubmed: 28599081
Respir Med. 2013 Nov;107(11):1675-81
pubmed: 24018107