Neuropharmacological Effects of Mesaconitine: Evidence from Molecular and Cellular Basis of Neural Circuit.
Journal
Neural plasticity
ISSN: 1687-5443
Titre abrégé: Neural Plast
Pays: United States
ID NLM: 100883417
Informations de publication
Date de publication:
2020
2020
Historique:
received:
25
05
2020
revised:
27
06
2020
accepted:
16
07
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
4
8
2021
Statut:
epublish
Résumé
Mesaconitine (MA), a diester-diterpenoid alkaloid in aconite roots, is considered to be one of the most important bioactive ingredients. In this review, we summarized its neuropharmacological effects, including analgesic effects and antiepileptiform effects. Mesaconitine can act on the central noradrenergic system and the serotonin system; behaving like the norepinephrine reuptake inhibitors and tricyclic antidepressants that increase norepinephrine levels in stress-induced depression. Therefore, the possible perspectives for future studies on the depression of MA were also discussed as well. The pharmacological effect of MA on depression is worthy of further study.
Identifiants
pubmed: 32904549
doi: 10.1155/2020/8814531
pmc: PMC7456483
doi:
Substances chimiques
Analgesics, Non-Narcotic
0
Anticonvulsants
0
Antidepressive Agents
0
mesaconitine
621OT356HL
Aconitine
X8YN71D5WC
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
8814531Informations de copyright
Copyright © 2020 Zhihui Sun et al.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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