HCV genotypes and their determinative role in hepatitis C treatment.
Antiviral agent
Hepatitis C virus
Hepatitis virus
Interferon
Journal
Virusdisease
ISSN: 2347-3584
Titre abrégé: Virusdisease
Pays: India
ID NLM: 101624144
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
27
08
2019
accepted:
24
04
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
10
9
2020
Statut:
ppublish
Résumé
Nowadays, exposure to infectious diseases caused by pathogenic viruses has become one of the major human concerns in health fields. In the meantime, hepatitis viruses are associated with health problems, especially in liver tissue. So far, several types of these viruses have been known including: HAV, HBV, HCV, HDV, HEV, and HGV. Nevertheless, it seems that hepatitis C is the major viral infection among all of the hepatitis infections. The cirrhosis and hepatocellular carcinoma are known as the most important pathological complications of this virus, from which seven genotypes have been identified. However, among these genotypes, the incidence rate of genotypes 1 and 3 is more than others. In this review, we have investigated the relationship between all HCV genotypes and therapeutic responses against them. Regarding heterogeneity between hepatitis C genotypes, it is not possible to access an effective vaccine against this virus, and treatment is the only applicable strategy. Response to treatment is different among genotypes, and it has resulted that each genotype has a specific therapeutic regimen of itself. Therefore, it seems that determination of hepatitis C genotype, as a key tool, is essential in controlling therapeutic regimen, improving local control programs and eventually producing an effective vaccine.
Identifiants
pubmed: 32904762
doi: 10.1007/s13337-020-00592-0
pii: 592
pmc: PMC7459022
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
235-240Informations de copyright
© Indian Virological Society 2020.
Déclaration de conflit d'intérêts
Conflict of interestNone to be declared.
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