Enteric Glia Modulate Macrophage Phenotype and Visceral Sensitivity following Inflammation.
abdominal pain
enteric nervous system
functional bowel disorders
glia
muscularis macrophage
neuroimmune
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
08 09 2020
08 09 2020
Historique:
received:
15
08
2019
revised:
02
07
2020
accepted:
11
08
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
29
5
2021
Statut:
ppublish
Résumé
Mechanisms resulting in abdominal pain include altered neuro-immune interactions in the gastrointestinal tract, but the signaling processes that link immune activation with visceral hypersensitivity are unresolved. We hypothesized that enteric glia link the neural and immune systems of the gut and that communication between enteric glia and immune cells modulates the development of visceral hypersensitivity. To this end, we manipulated a major mechanism of glial intercellular communication that requires connexin-43 and assessed the effects on acute and chronic inflammation, visceral hypersensitivity, and immune responses. Deleting connexin-43 in glia protected against the development of visceral hypersensitivity following chronic colitis. Mechanistically, the protective effects of glial manipulation were mediated by disrupting the glial-mediated activation of macrophages through the macrophage colony-stimulating factor. Collectively, our data identified enteric glia as a critical link between gastrointestinal neural and immune systems that could be harnessed by therapies to ameliorate abdominal pain.
Identifiants
pubmed: 32905782
pii: S2211-1247(20)31089-5
doi: 10.1016/j.celrep.2020.108100
pmc: PMC7518300
mid: NIHMS1627851
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108100Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK103723
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK108894
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK113943
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK120862
Pays : United States
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
Références
Pain. 2014 Oct;155(10):1962-75
pubmed: 24972070
Oncotarget. 2016 Jan 12;7(2):1354-66
pubmed: 26595525
Genes Dev. 2001 Jan 1;15(1):66-78
pubmed: 11156606
PLoS One. 2017 Apr 20;12(4):e0176031
pubmed: 28426719
Cell Rep. 2012 Sep 27;2(3):511-7
pubmed: 22921401
Semin Cell Dev Biol. 2016 Feb;50:49-58
pubmed: 26688335
Biochem Pharmacol. 2012 Dec 1;84(11):1459-69
pubmed: 23000912
Gut. 2018 Feb;67(2):255-262
pubmed: 28104632
Glia. 2015 Nov;63(11):2040-2057
pubmed: 26119414
Gut. 2014 Jan;63(1):105-15
pubmed: 23292665
J Exp Med. 1972 Apr 1;135(4):780-92
pubmed: 5018051
Cell Mol Gastroenterol Hepatol. 2015 Mar 1;1(2):154-170
pubmed: 26000334
Cell. 2014 Aug 28;158(5):1210
pubmed: 28917294
J Neurophysiol. 2017 Jan 1;117(1):365-375
pubmed: 27784805
Am J Physiol Gastrointest Liver Physiol. 2017 Dec 1;313(6):G570-G580
pubmed: 28838986
Cell Mol Gastroenterol Hepatol. 2018 May 29;6(3):321-344
pubmed: 30116771
Histochem Cell Biol. 2003 Jul;120(1):51-61
pubmed: 12811573
J Physiol. 2017 Jan 15;595(2):557-570
pubmed: 27106597
Cell Motil Cytoskeleton. 2009 Nov;66(11):1000-16
pubmed: 19544403
Gastroenterol Res Pract. 2016;2016:2031480
pubmed: 28115927
Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11235-11240
pubmed: 28973941
Pain. 2013 Dec;154 Suppl 1:S10-28
pubmed: 23792284
Inflamm Bowel Dis. 2009 Nov;15(11):1678-85
pubmed: 19408320
J Neurosci Res. 2009 Jul;87(9):2095-104
pubmed: 19235895
Cell Mol Gastroenterol Hepatol. 2016 Jan 1;2(1):77-91
pubmed: 26771001
Crit Rev Immunol. 2008;28(3):215-27
pubmed: 19024346
Cell. 1982 Jan;28(1):71-81
pubmed: 6978185
Front Cell Neurosci. 2018 Dec 04;12:467
pubmed: 30564102
J Neurogastroenterol Motil. 2017 Apr 30;23(2):281-288
pubmed: 28044051
Nat Rev Gastroenterol Hepatol. 2014 Oct;11(10):611-27
pubmed: 25001973
Brain Behav Immun. 2018 Feb;68:248-260
pubmed: 29080683
Neuroscientist. 2019 Jun;25(3):227-240
pubmed: 29931997
J Neurochem. 2002 Nov;83(3):556-64
pubmed: 12390517
J Immunother Cancer. 2017 Jul 18;5(1):53
pubmed: 28716061
Gastroenterology. 2008 Jun;134(7):2059-69
pubmed: 18343379
Cell Tissue Res. 2007 Feb;327(2):333-42
pubmed: 17058052
J Immunol. 2007 Nov 15;179(10):6715-24
pubmed: 17982061
J Vis Exp. 2013 Aug 07;(78):
pubmed: 23962959
Gut. 2004 Feb;53(2):222-8
pubmed: 14724154
Eur J Pharmacol. 2018 Jan 5;818:578-584
pubmed: 29162434
Gastroenterol Hepatol (N Y). 2018 Apr;14(4):250-252
pubmed: 29942225
Neurogastroenterol Motil. 2017 May;29(5):
pubmed: 27981684
FEBS Lett. 2014 Apr 17;588(8):1193-204
pubmed: 24561196
Neurogastroenterol Motil. 2016 Nov;28(11):1632-1640
pubmed: 27196538
Histochem Cell Biol. 2006 Nov;126(5):537-48
pubmed: 16733665
Am J Pathol. 1994 Jul;145(1):48-53
pubmed: 8030755
Proc Natl Acad Sci U S A. 2018 May 1;115(18):4696-4701
pubmed: 29666241
Immunity. 2017 Jun 20;46(6):927-942
pubmed: 28636960
Am J Physiol Gastrointest Liver Physiol. 2015 Jul 15;309(2):G87-99
pubmed: 26021808
Proc Natl Acad Sci U S A. 1987 Sep;84(17):6179-83
pubmed: 2819867
Gastroenterology. 2014 Jan;146(1):166-75
pubmed: 24055279
Q Rev Biophys. 2001 Aug;34(3):325-472
pubmed: 11838236
Front Cell Neurosci. 2015 Oct 08;9:403
pubmed: 26528133
J Physiol. 2003 Aug 1;550(Pt 3):829-44
pubmed: 12844505
Eur J Pain. 2017 Apr;21(4):623-634
pubmed: 27748566
Gut. 2010 Apr;59(4):481-8
pubmed: 20332520
Am J Physiol Gastrointest Liver Physiol. 2017 Feb 1;312(2):G145-G152
pubmed: 28039160
Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315(1):G140-G157
pubmed: 29565640
Inflamm Bowel Dis. 2016 Aug;22(8):1812-34
pubmed: 27416040
Am J Physiol Gastrointest Liver Physiol. 2004 Sep;287(3):G647-57
pubmed: 15331354
Nat Med. 2012 Mar 18;18(4):600-4
pubmed: 22426419
Am J Physiol Gastrointest Liver Physiol. 2012 May 15;302(10):G1085-98
pubmed: 22403791
Cell Mol Gastroenterol Hepatol. 2019;7(2):433-445
pubmed: 30739868
Cell Mol Gastroenterol Hepatol. 2016 Mar 1;2(2):120-130.e1
pubmed: 27047989
Pain. 2002 Jan;95(1-2):41-7
pubmed: 11790466
Behring Inst Mitt. 1988 Aug;(83):15-26
pubmed: 3071332
J Physiol. 2008 Nov 1;586(21):5247-58
pubmed: 18755744
Sci Rep. 2019 Jan 23;9(1):387
pubmed: 30674925
Cell Rep. 2017 Dec 12;21(11):3102-3115
pubmed: 29241539
Trends Cell Biol. 2004 Nov;14(11):628-38
pubmed: 15519852
J Neurosci. 2008 Dec 24;28(52):14062-73
pubmed: 19109489
Clin Sci (Lond). 2015 Aug;129(3):281-90
pubmed: 25896238
Gastroenterology. 2014 Feb;146(2):497-507.e1
pubmed: 24211490
J Neuroendocrinol. 2006 Nov;18(11):820-5
pubmed: 17026531
Nat Neurosci. 2016 Jan;19(1):94-101
pubmed: 26642091
J Physiol. 2017 Jun 1;595(11):3409-3424
pubmed: 28066889
Am J Physiol Gastrointest Liver Physiol. 2004 Oct;287(4):G845-55
pubmed: 15205116
J Vis Exp. 2012 Feb 01;(60):
pubmed: 22331082
J Neuroimmunol. 1992 Oct;40(2-3):189-95
pubmed: 1430151
Gastroenterology. 2015 Dec;149(7):1731-1741.e3
pubmed: 26327134
Nat Protoc. 2017 Jul;12(7):1295-1309
pubmed: 28569761
Science. 2016 Nov 4;354(6312):572-577
pubmed: 27811267
J Clin Invest. 2011 Sep;121(9):3412-24
pubmed: 21865647
Front Mol Neurosci. 2017 Nov 16;10:374
pubmed: 29200997
Stress. 2010 Jul;13(4):343-54
pubmed: 20536336
PLoS Genet. 2017 Mar 6;13(3):e1006641
pubmed: 28263993
Gastroenterology. 2018 Feb;154(3):723-735
pubmed: 29288656
J Neurochem. 1996 Feb;66(2):604-12
pubmed: 8592130
Gastroenterology. 2016 Feb 18;:
pubmed: 27144627
Nat Rev Gastroenterol Hepatol. 2012 Nov;9(11):625-32
pubmed: 22890111
Br J Rheumatol. 1994 Jul;33(7):613-9
pubmed: 8019788
Gastroenterology. 2009 Dec;137(6):2084-2095.e3
pubmed: 19632231
Dig Dis Sci. 2011 Jan;56(1):79-89
pubmed: 20467900