Hemostasis and Liver Regeneration.
Journal
Seminars in thrombosis and hemostasis
ISSN: 1098-9064
Titre abrégé: Semin Thromb Hemost
Pays: United States
ID NLM: 0431155
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
24
6
2021
Statut:
ppublish
Résumé
The liver is unique in its remarkable regenerative capacity, which enables the use of liver resection as a treatment for specific liver diseases, including removal of neoplastic liver disease. After resection, the remaining liver tissue (i.e, liver remnant) regenerates to maintain normal hepatic function. In experimental settings as well as patients, removal of up to two-thirds of the liver mass stimulates a rapid and highly coordinated process resulting in the regeneration of the remaining liver. Mechanisms controlling the initiation and termination of regeneration continue to be discovered, and many of the fundamental signaling pathways controlling the proliferation of liver parenchymal cells (i.e., hepatocytes) have been uncovered. Interestingly, while hemostatic complications (i.e., bleeding and thrombosis) are primarily thought of as a complication of surgery itself, strong evidence suggests that components of the hemostatic system are, in fact, powerful drivers of liver regeneration. This review focuses on the clinical and translational evidence supporting a link between the hemostatic system and liver regeneration, and the mechanisms whereby the hemostatic system directs liver regeneration discovered using experimental settings.
Identifiants
pubmed: 32906177
doi: 10.1055/s-0040-1715450
pmc: PMC7895330
mid: NIHMS1671878
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
735-742Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK120289
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK122813
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES017537
Pays : United States
Organisme : R01 ES017537
ID : National Institutes of Health (NIH)
Organisme : DK120289
ID : National Institutes of Health (NIH)
Informations de copyright
Thieme. All rights reserved.
Déclaration de conflit d'intérêts
Dr. Groeneveld reports grants from the European Hematology Association during the conduct of the study. Dr. Luyendyk reports grants from the National Institutes of Health during the conduct of the study.
Références
Biosci Biotechnol Biochem. 2017 Nov;81(11):2105-2111
pubmed: 28914172
Platelets. 2015;26(4):286-92
pubmed: 25806786
J Clin Oncol. 2008 Aug 1;26(22):3672-80
pubmed: 18669451
HPB (Oxford). 2020 Jun;22(6):884-891
pubmed: 31680011
Br J Surg. 2003 Nov;90(11):1384-90
pubmed: 14598419
J Am Coll Surg. 2007 May;204(5):854-62; discussion 862-4
pubmed: 17481498
Hepatology. 2016 May;63(5):1675-88
pubmed: 26528955
Blood. 2013 Feb 7;121(6):1008-15
pubmed: 23243271
J Hepatol. 2010 Oct;53(4):648-54
pubmed: 20615569
Hepatology. 1998 Jan;27(1):62-6
pubmed: 9425918
Comp Hepatol. 2004 Sep 01;3(1):7
pubmed: 15341660
Am J Physiol Gastrointest Liver Physiol. 2013 Mar 1;304(5):G469-78
pubmed: 23257923
Ann Surg. 2011 Apr;253(4):759-63
pubmed: 21475016
Br J Surg. 2016 May;103(6):735-743
pubmed: 27005894
Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15143-8
pubmed: 10611352
Ann Surg Oncol. 2015 Sep;22(9):3109-20
pubmed: 25448799
Gastroenterology. 2003 Mar;124(3):692-700
pubmed: 12612908
Br J Cancer. 2006 Apr 10;94(7):982-99
pubmed: 16538219
Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G963-8
pubmed: 19246633
Am J Physiol. 1998 Dec;275(6):G1472-9
pubmed: 9843786
Hepatology. 2016 Nov;64(5):1711-1724
pubmed: 27397846
World J Surg. 2007 Apr;31(4):808-16
pubmed: 17354025
Ann Surg. 2008 Nov;248(5):821-8
pubmed: 18948810
Transplantation. 2014 May 15;97(9):892-900
pubmed: 24621531
Nature. 1998 Aug 13;394(6694):690-4
pubmed: 9716134
Hepatology. 1997 Oct;26(4):896-904
pubmed: 9328311
Blood. 2010 Aug 19;116(7):1147-56
pubmed: 20439620
Clin Chem Lab Med. 2004 Mar;42(3):261-5
pubmed: 15080557
Anesth Analg. 2008 Jan;106(1):32-44, table of contents
pubmed: 18165548
Eur Surg Res. 2015;54(3-4):148-61
pubmed: 25592812
Toxicol Sci. 2018 Apr 1;162(2):396-405
pubmed: 29228388
N Engl J Med. 2007 Apr 12;356(15):1545-59
pubmed: 17429086
J Thromb Haemost. 2007 Oct;5(10):2009-16
pubmed: 17650077
J Gastrointest Surg. 2018 Feb;22(2):203-213
pubmed: 28766271
Am J Pathol. 2010 Jan;176(1):2-13
pubmed: 20019184
Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):E2165-72
pubmed: 22753481
Liver. 2000 Feb;20(1):66-77
pubmed: 10726963
Arterioscler Thromb Vasc Biol. 1999 Feb;19(2):281-9
pubmed: 9974408
Cell. 2003 Dec 26;115(7):851-62
pubmed: 14697203
Blood. 2008 Feb 1;111(3):1227-33
pubmed: 17962514
Toxicol Sci. 2014 Oct;141(2):453-64
pubmed: 25015658
Blood. 2019 Mar 14;133(11):1245-1256
pubmed: 30655274
J Surg Res. 2008 Apr;145(2):279-86
pubmed: 17688880
Expert Rev Gastroenterol Hepatol. 2014 Nov;8(8):897-907
pubmed: 24964729
Biochem Biophys Res Commun. 2000 Dec 29;279(3):974-9
pubmed: 11162460
Surgery. 2004 Nov;136(5):1028-37
pubmed: 15523397
Hepatology. 2018 Apr;67(4):1516-1530
pubmed: 29140542
Blood. 2012 Jun 28;119(26):6288-95
pubmed: 22596260
Nat Protoc. 2008;3(7):1167-70
pubmed: 18600221
J Hepatol. 2002 Oct;37(4):471-7
pubmed: 12217600
Hepatology. 2016 Sep;64(3):992-3
pubmed: 26799443
Langenbecks Arch Surg. 2012 Apr;397(4):579-90
pubmed: 22311102
J Cell Physiol. 2007 Nov;213(2):286-300
pubmed: 17559071
J Clin Invest. 1997 Feb 15;99(4):737-44
pubmed: 9045878
Ann Surg Oncol. 2006 Oct;13(10):1271-80
pubmed: 16955381
Blood. 2012 Jul 5;120(1):199-206
pubmed: 22589474
J Hepatol. 2017 Dec;67(6):1243-1252
pubmed: 28842294
J Clin Oncol. 2009 Aug 1;27(22):3677-83
pubmed: 19470929
J Clin Transl Res. 2016 Aug 3;2(3):97-106
pubmed: 30873468
Liver Int. 2006 Apr;26(3):352-61
pubmed: 16584399
Blood. 2011 Aug 4;118(5):1359-69
pubmed: 21680800
Blood. 2014 Jul 24;124(4):493-502
pubmed: 24904119
Surg Today. 1999;29(1):1-9
pubmed: 9934824
Microcirculation. 2008 Jan;15(1):37-47
pubmed: 17952799
Science. 2006 Apr 7;312(5770):104-7
pubmed: 16601191
In Vitro. 1982 Feb;18(2):108-16
pubmed: 7044955
Hepatology. 2015 Nov;62(5):1593-605
pubmed: 26202541
Blood. 2011 Apr 7;117(14):3907-11
pubmed: 21330475
J Surg Res. 2013 Mar;180(1):62-72
pubmed: 23260232
Hepatology. 2017 Apr;65(4):1384-1392
pubmed: 27997988
Br J Surg. 2003 Jan;90(1):33-41
pubmed: 12520572
Liver Int. 2015 Jul;35(7):1809-15
pubmed: 25522671
Blood. 2016 Aug 4;128(5):625-9
pubmed: 27297793
Swiss Med Wkly. 2008 Jun 28;138(25-26):361-70
pubmed: 18587687
Eur J Surg Oncol. 2015 May;41(5):674-82
pubmed: 25630689
World J Surg. 2008 Jun;32(6):1088-96
pubmed: 18311501
Hepatology. 2011 Apr;53(4):1323-32
pubmed: 21480334
PLoS One. 2017 Dec 8;12(12):e0188921
pubmed: 29220362
Hepatobiliary Surg Nutr. 2019 Aug;8(4):329-337
pubmed: 31489302
Thromb Res. 2014 May;133 Suppl 1:S57-9
pubmed: 24759146
Liver Int. 2017 Nov;37(11):1731-1737
pubmed: 28178387
Hepatology. 2014 Jul;60(1):257-66
pubmed: 24277679
Blood. 2015 Aug 6;126(6):798-806
pubmed: 26056167
J Thromb Haemost. 2009 Jul;7(7):1163-71
pubmed: 19426283
J Hepatobiliary Pancreat Surg. 1999;6(3):275-80
pubmed: 10526063
Eur J Cancer. 2006 Sep;42(14):2212-21
pubmed: 16904315
Liver Int. 2014 Aug;34(7):1049-56
pubmed: 24119092
N Engl J Med. 2012 Aug 23;367(8):716-24
pubmed: 22913681
Expert Rev Gastroenterol Hepatol. 2016;10(5):557-9
pubmed: 26909855
J Hepatol. 2008 Sep;49(3):363-72
pubmed: 18602717
Lab Anim. 2015 Apr;49(1 Suppl):81-8
pubmed: 25835741
Ann R Coll Surg Engl. 2003 Sep;85(5):334-9
pubmed: 14594539
Ann Hepatol. 2016 Sep-Oct;15(5):762-72
pubmed: 27493116