The Light and Shadow of Rapid Serological Tests for SARS-CoV-2 Infection: Results from a Study in a Large Emergency Department.
Antibodies, Viral
/ blood
Betacoronavirus
/ isolation & purification
COVID-19
COVID-19 Testing
Clinical Laboratory Techniques
/ methods
Coronavirus Infections
/ diagnosis
Emergency Service, Hospital
/ statistics & numerical data
Humans
Immunoglobulin G
/ blood
Pandemics
Pneumonia, Viral
/ diagnosis
Real-Time Polymerase Chain Reaction
SARS-CoV-2
Sensitivity and Specificity
Serologic Tests
/ methods
COVID-19
SARS-CoV-2 infection
laboratory test
real-time PCR
serological test
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
07 09 2020
07 09 2020
Historique:
received:
22
07
2020
revised:
27
08
2020
accepted:
04
09
2020
entrez:
10
9
2020
pubmed:
11
9
2020
medline:
20
9
2020
Statut:
epublish
Résumé
A critical point in the management of the SARS-CoV-2 pandemic is the need to promptly identify the greatest number of infected people and to implement strict public health measures. In this study, the performance of a rapid serological test in a clinical setting was evaluated. Samples from 819 consecutive patients (with or without respiratory symptoms) admitted to a large Emergency Department were tested between 23 March and 21 April 2020. Patient samples were tested in a real-time PCR assay and a serological assay. In total, 148/819 patients (18.1%) tested positive for SARS-CoV-2 by real-time PCR. The serological test revealed that 70/819 patients (8.5%) had anti-SARS-CoV-2 IgM and/or IgG. The prevalence of anti-SARS-CoV-2 antibodies was significantly higher in patients with respiratory symptoms lasting for >7 days than in those with respiratory symptoms lasting for 0-7 days (
Identifiants
pubmed: 32906596
pii: ijerph17186493
doi: 10.3390/ijerph17186493
pmc: PMC7558531
pii:
doi:
Substances chimiques
Antibodies, Viral
0
Immunoglobulin G
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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