pH-Responsive and Biodegradable ZnO-Capped Mesoporous Silica Composite Nanoparticles for Drug Delivery.
ZnO QDs
mesoporous silica composite nanoparticles (MSCNs)
pH-responsive biodegradability
pH-responsive drug delivery
Journal
Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929
Informations de publication
Date de publication:
07 Sep 2020
07 Sep 2020
Historique:
received:
14
07
2020
revised:
19
08
2020
accepted:
31
08
2020
entrez:
10
9
2020
pubmed:
11
9
2020
medline:
11
9
2020
Statut:
epublish
Résumé
As a drug delivery system (DDS), traditional mesoporous silica nanoparticles (MSNs) suffer from bioaccumulation in vivo and premature drug release in systemic circulation due to low degradation rate and lack of protective gatekeeper. Herein, we developed a safe and intelligent DDS with characteristics of pH-responsive biodegradation and controlled drug release based on mesoporous silica composite nanoparticles (MSCNs) capped with ZnO quantum dots (ZnO QDs). Acidic degradable MSCNs were successfully synthesized by doping Ca
Identifiants
pubmed: 32906723
pii: ma13183950
doi: 10.3390/ma13183950
pmc: PMC7558045
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fundamental Research Funds for the Central Universities
ID : 2018BSCXB11
Organisme : Postgraduate Research & Practice Innovation Program of Jiangsu Province
ID : KYCX18_1937
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