Dual-Hormone Closed-Loop System Using a Liquid Stable Glucagon Formulation Versus Insulin-Only Closed-Loop System Compared With a Predictive Low Glucose Suspend System: An Open-Label, Outpatient, Single-Center, Crossover, Randomized Controlled Trial.
Adult
Blood Glucose
/ analysis
Cross-Over Studies
Diabetes Mellitus, Type 1
/ blood
Exercise
/ physiology
Feasibility Studies
Female
Glucagon
/ administration & dosage
Humans
Hyperglycemia
/ chemically induced
Hypoglycemia
/ chemically induced
Hypoglycemic Agents
/ administration & dosage
Insulin
/ administration & dosage
Insulin Infusion Systems
Male
Middle Aged
Oregon
Outpatients
Pancreas, Artificial
Young Adult
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
11
11
2019
accepted:
16
08
2020
pubmed:
11
9
2020
medline:
25
5
2021
entrez:
10
9
2020
Statut:
ppublish
Résumé
To assess the efficacy and feasibility of a dual-hormone (DH) closed-loop system with insulin and a novel liquid stable glucagon formulation compared with an insulin-only closed-loop system and a predictive low glucose suspend (PLGS) system. In a 76-h, randomized, crossover, outpatient study, 23 participants with type 1 diabetes used three modes of the Oregon Artificial Pancreas system: DH reduced hypoglycemia compared with SH during and after exercise (DH 0.0% [interquartile range 0.0-4.2], SH 8.3% [0.0-12.5], The glucagon formulation demonstrated feasibility in a closed-loop system. The DH system reduced hypoglycemia during and after exercise, with some increase in hyperglycemia.
Identifiants
pubmed: 32907828
pii: dc19-2267
doi: 10.2337/dc19-2267
doi:
Substances chimiques
Blood Glucose
0
Hypoglycemic Agents
0
Insulin
0
Glucagon
9007-92-5
Banques de données
ClinicalTrials.gov
['NCT03424044']
figshare
['10.2337/figshare.12815861']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2721-2729Informations de copyright
© 2020 by the American Diabetes Association.