No radiographic sacroiliitis progression was observed in patients with early spondyloarthritis at 6 years: results of the Esperanza multicentric prospective cohort.
Ankylosing
Healthcare
Outcome Assessment
Outcome and Process Assessment
Spondylitis
Journal
RMD open
ISSN: 2056-5933
Titre abrégé: RMD Open
Pays: England
ID NLM: 101662038
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
28
05
2020
revised:
30
07
2020
accepted:
21
08
2020
entrez:
10
9
2020
pubmed:
11
9
2020
medline:
2
7
2021
Statut:
ppublish
Résumé
To estimate the 6-year radiographic progression of sacroiliitis in patients with early spondyloarthritis (SpA). Sacroiliac joint (SIJ) radiographs (baseline and 6 years) of 94 patients with recent-onset SpA from the Esperanza cohort were scored, blindly and in a random order, by nine readers. The modified New York criteria were used to define the presence of sacroiliitis. As the gold standard for radiographic (r) sacroiliitis, the categorical opinion of at least five readers was used. Progression was defined as the shift from non-radiographic (nr) to r-sacroiliitis. In the 94 SIJ radiographs (baseline and 6 years), 78/94 (83%) pairs of radiographs had not changed from baseline to 6 years. Sacroiliitis was present in 20 patients at baseline (21.3%) and in 18 (19.2%) patients at 6 years; 11 patients had sacroiliitis at both the baseline and final visits; 9 patients changed from baseline r-sacroiliitis to nr-sacroiliitis at 6 years, and 7 changed from baseline nr-sacroiliitis to r-sacroiliitis at 6 years. The mean continuous change score (range: -8 to +8) was 2.80 at baseline and 2.55 at 6 years (mean net progression of -0.25). The reliability of the readers was fair (mean inter-reader kappa of 0.375 (0.146-0.652) and mean agreement of 73.7% (58.7-90%)). In the early SpA Esperanza cohort, progression from nr-axSpA to r-axSpA over 6 years was not observed, although the SIJ radiographs scoring has limitations to detect low levels of radiographic progression.
Identifiants
pubmed: 32907882
pii: rmdopen-2020-001345
doi: 10.1136/rmdopen-2020-001345
pmc: PMC7520544
pii:
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Ann Rheum Dis. 2012 Dec;71(12):1998-2001
pubmed: 22915622
J Rheumatol. 2017 Jan;44(1):1-3
pubmed: 28042123
Ann Rheum Dis. 2003 Jun;62(6):519-25
pubmed: 12759287
Ann Rheum Dis. 1987 Feb;46(2):139-45
pubmed: 3827336
Ann Rheum Dis. 2011 May;70(5):827-30
pubmed: 21242234
Ann Rheum Dis. 2011 Aug;70(8):1369-74
pubmed: 21622969
J Rheumatol. 2003 Dec;30(12):2632-7
pubmed: 14719206
Arthritis Rheumatol. 2014 Sep;66(9):2403-11
pubmed: 24909765
Arthritis Rheumatol. 2015 Sep;67(9):2369-75
pubmed: 26017497
Ann Rheum Dis. 2016 Jun;75(6):1262-3
pubmed: 26903442
Rheumatology (Oxford). 2017 Oct 1;56(10):1740-1745
pubmed: 28957558
Ann Rheum Dis. 2009 Jun;68(6):777-83
pubmed: 19297344
Expert Rev Clin Immunol. 2018 Jun;14(6):525-533
pubmed: 29774755
Arthritis Rheum. 2009 Mar;60(3):717-27
pubmed: 19248087
Ann Rheum Dis. 2017 Nov;76(11):1823-1828
pubmed: 28684556
Ann Rheum Dis. 2015 Jul;74(7):1327-39
pubmed: 25837448
Arthritis Rheum. 1984 Apr;27(4):361-8
pubmed: 6231933
Rheum Dis Clin North Am. 2018 May;44(2):307-315
pubmed: 29622297
J Rheumatol. 2017 Jan;44(1):70-77
pubmed: 27744397
RMD Open. 2019 Feb 26;5(1):e000848
pubmed: 30886736