Membrane-bound

Animals Carrier Proteins / genetics Cell Membrane / metabolism Diglycerides / metabolism Gene Knockout Techniques Insulin Resistance Liver / metabolism Mice Non-alcoholic Fatty Liver Disease / genetics
diabetes drug therapy lipids liver liver microsomal triglyceride transfer protein liver-targeted mitochondrial uncoupler metabolic disease nonalcoholic fatty liver disease

Journal

Journal of lipid research
ISSN: 1539-7262
Titre abrégé: J Lipid Res
Pays: United States
ID NLM: 0376606

Informations de publication

Date de publication:
12 2020
Historique:
pubmed: 11 9 2020
medline: 26 10 2021
entrez: 10 9 2020
Statut: ppublish

Résumé

Microsomal triglyceride transfer protein (MTTP) deficiency results in a syndrome of hypolipidemia and accelerated NAFLD. Animal models of decreased hepatic MTTP activity have revealed an unexplained dissociation between hepatic steatosis and hepatic insulin resistance. Here, we performed comprehensive metabolic phenotyping of liver-specific MTTP knockout (L-

Identifiants

DOI: 10.1194/jlr.RA119000586 PMID: 32907986 PMC: PMC7707176
pubmed: 32907986
pii: S0022-2275(20)60019-0
doi: 10.1194/jlr.RA119000586
pmc: PMC7707176
pii:
doi:

Substances chimiques

1,2-diacylglycerol 0
Carrier Proteins 0
Diglycerides 0
microsomal triglyceride transfer protein 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1565-1576

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL137202
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK113984
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK121490
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK116774
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK119968
Pays : United States
Organisme : BLRD VA
ID : I01 BX004113
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK045735
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK102874
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK034989
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK114793
Pays : United States
Organisme : BLRD VA
ID : I01 BX000901
Pays : United States

Informations de copyright

Copyright © 2020 Abulizi et al. Published by The American Society for Biochemistry and Molecular Biology, Inc.

Déclaration de conflit d'intérêts

Conflict of interest—G.I.S. is an inventor on the Yale University patent for CRMP and scientific co-founder of TLC Inc., which is developing livertargeted mitochondrial agents (including CRMP) for the treatment of NAFLD/NASH and associated metabolic diseases. There are no other conflicts of interest with the contents of this article.

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Auteurs

Abudukadier Abulizi (A)

Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.

Daniel F Vatner (DF)

Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.

Zhang Ye (Z)

Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.

Yongliang Wang (Y)

Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.

Joao-Paulo Camporez (JP)

Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.

Dongyan Zhang (D)

Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.

Mario Kahn (M)

Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.

Kun Lyu (K)

Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.

Alaa Sirwi (A)

Departments of Cell Biology and Pediatrics, SUNY Downstate Medical Center, Mineola, NY, USA.

Gary W Cline (GW)

Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.

M Mahmood Hussain (MM)

Departments of Cell Biology and Pediatrics, SUNY Downstate Medical Center, Mineola, NY, USA; Department of Foundations of Medicine, NYU Long Island School of Medicine, Mineola, NY, USA.

Patricia Aspichueta (P)

Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, Leioa, Spain; Biocruces Research Institute, Barakaldo, Spain.

Varman T Samuel (VT)

Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA; Veterans Affairs Medical Center, West Haven, CT, USA.

Gerald I Shulman (GI)

Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA. Electronic address: gerald.shulman@yale.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Membrane-bound
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Membrane-bound
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Membrane-bound
questionsmedicales.fr › Lipides › Glycérides › Diglycéride › Membrane-bound
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-out de gènes › Membrane-bound
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › Membrane-bound
questionsmedicales.fr › Système digestif › Foie › Membrane-bound
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Membrane-bound
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Stéatose hépatique › Stéatose hépatique non alcoolique › Membrane-bound