Discovery of a selective, state-independent inhibitor of Na

Animals Drug Discovery Ganglia, Spinal / metabolism Guanidine / chemistry Humans NAV1.1 Voltage-Gated Sodium Channel / chemistry NAV1.2 Voltage-Gated Sodium Channel / chemistry NAV1.3 Voltage-Gated Sodium Channel / chemistry NAV1.4 Voltage-Gated Sodium Channel / chemistry NAV1.5 Voltage-Gated Sodium Channel / chemistry NAV1.6 Voltage-Gated Sodium Channel / chemistry NAV1.7 Voltage-Gated Sodium Channel / chemistry NAV1.8 Voltage-Gated Sodium Channel / chemistry Protein Structure, Secondary Sodium Channel Blockers / chemistry

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
09 09 2020
Historique:
received: 16 04 2020
accepted: 06 08 2020
entrez: 10 9 2020
pubmed: 11 9 2020
medline: 18 5 2021
Statut: epublish

Résumé

The voltage-gated sodium channel isoform Na

Identifiants

DOI: 10.1038/s41598-020-71135-2 PMID: 32908170 PMC: PMC7481244
pubmed: 32908170
doi: 10.1038/s41598-020-71135-2
pii: 10.1038/s41598-020-71135-2
pmc: PMC7481244
doi:

Substances chimiques

NAV1.1 Voltage-Gated Sodium Channel 0
NAV1.2 Voltage-Gated Sodium Channel 0
NAV1.3 Voltage-Gated Sodium Channel 0
NAV1.4 Voltage-Gated Sodium Channel 0
NAV1.5 Voltage-Gated Sodium Channel 0
NAV1.6 Voltage-Gated Sodium Channel 0
NAV1.7 Voltage-Gated Sodium Channel 0
NAV1.8 Voltage-Gated Sodium Channel 0
Sodium Channel Blockers 0
Guanidine JU58VJ6Y3B

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

14791

Subventions

Organisme : NINDS NIH HHS
ID : R44 NS081887
Pays : United States
Organisme : NIH HHS
ID : R01 GM117263-01A1
Pays : United States

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Auteurs

H Pajouhesh (H)

SiteOne Therapeutics, South San Francisco, CA, 94080, USA.

J T Beckley (JT)

SiteOne Therapeutics, Bozeman, MT, 59715, USA.

A Delwig (A)

SiteOne Therapeutics, South San Francisco, CA, 94080, USA.

H S Hajare (HS)

Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.

G Luu (G)

SiteOne Therapeutics, South San Francisco, CA, 94080, USA.

D Monteleone (D)

SiteOne Therapeutics, South San Francisco, CA, 94080, USA.

X Zhou (X)

SiteOne Therapeutics, South San Francisco, CA, 94080, USA.

J Ligutti (J)

Neuroscience Department, Amgen Research, Thousand Oaks, CA, 91320, USA.

S Amagasu (S)

Neuroscience Department, Amgen Research, Thousand Oaks, CA, 91320, USA.

B D Moyer (BD)

Neuroscience Department, Amgen Research, Thousand Oaks, CA, 91320, USA.

D C Yeomans (DC)

Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, 94305, USA.

J Du Bois (J)

Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.

J V Mulcahy (JV)

SiteOne Therapeutics, South San Francisco, CA, 94080, USA. john.mulcahy@site1therapeutics.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Discovery of a selective, state-independent...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Discovery of a selective, state-independent...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Nerfs périphériques › Nerfs spinaux › Racines des nerfs spinaux › Ganglions sensitifs des nerfs spinaux › Discovery of a selective, state-independent...
questionsmedicales.fr › Composés chimiques organiques › Amidines › Guanidines › Guanidine › Discovery of a selective, state-independent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Discovery of a selective, state-independent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Canaux sodiques voltage-dépendants › Canal sodique voltage-dépendant NAV1.1 › Discovery of a selective, state-independent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Canaux sodiques voltage-dépendants › Canal sodique voltage-dépendant NAV1.2 › Discovery of a selective, state-independent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Canaux sodiques voltage-dépendants › Canal sodique voltage-dépendant NAV1.3 › Discovery of a selective, state-independent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux sodiques › Canal sodique voltage-dépendant NAV1.4 › Discovery of a selective, state-independent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Canaux sodiques voltage-dépendants › Canal sodique voltage-dépendant NAV1.5 › Discovery of a selective, state-independent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Canaux sodiques voltage-dépendants › Canal sodique voltage-dépendant NAV1.6 › Discovery of a selective, state-independent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Canaux sodiques voltage-dépendants › Canal sodique voltage-dépendant NAV1.7 › Discovery of a selective, state-independent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Canaux sodiques voltage-dépendants › Canal sodique voltage-dépendant NAV1.8 › Discovery of a selective, state-independent...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Discovery of a selective, state-independent...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Bloqueurs de canaux sodiques › Discovery of a selective, state-independent...