Prophylaxis of Upper Airway Infections in a Patient with Partial IgA Deficiency: Concurrent Use of Sublingual Immunotherapy with Inactivated Whole-Cell Bacterial Extract and Der p1.
Journal
Case reports in otolaryngology
ISSN: 2090-6765
Titre abrégé: Case Rep Otolaryngol
Pays: United States
ID NLM: 101576603
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
01
2020
revised:
01
06
2020
accepted:
04
08
2020
entrez:
10
9
2020
pubmed:
11
9
2020
medline:
11
9
2020
Statut:
epublish
Résumé
Selective IgA deficiency is the most common type of primary immunodeficiency, but there is not yet a specific effective treatment. The most prevalent clinical manifestations are infectious diseases of the respiratory system. We report herein the case of an 11-year-old female with selective IgA deficiency and recurring episodes of respiratory infections associated with rhinitis and asthma. We evaluated the efficacy of sublingual immunotherapy combined with inactivated whole-cell bacterial extract and Der p1-specific immunotherapy. After 18 months of clinical follow-up, we observed a significant reduction in the number of episodes of respiratory infections associated with control of atopic diseases. We also observed a 3-fold increase in serum IgA levels compared to treatment initiation. This case demonstrates the potential utility of the concurrent use of sublingual immunotherapy with inactivated whole-cell bacterial extract and Der p1 for successful control of allergy and infection in partial selective IgA deficiency.
Identifiants
pubmed: 32908754
doi: 10.1155/2020/6313176
pmc: PMC7463416
doi:
Types de publication
Case Reports
Langues
eng
Pagination
6313176Informations de copyright
Copyright © 2020 Paula F. Aarestrup et al.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest regarding the publication of this paper.
Références
J Allergy Clin Immunol. 2006 Apr;117(4 Suppl):S525-53
pubmed: 16580469
Pulm Pharmacol Ther. 2012 Feb;25(1):62-8
pubmed: 22155205
Scand J Immunol. 2009 Dec;70(6):505-15
pubmed: 19906191
Int J Chron Obstruct Pulmon Dis. 2007;2(3):335-45
pubmed: 18229572
Chest. 1993 Jun;103(6):1783-91
pubmed: 8404101
Am J Clin Pathol. 1983 Aug;80(2):210-3
pubmed: 6410901
Asia Pac Allergy. 2015 Jul;5(3):163-9
pubmed: 26240793
J Biol Regul Homeost Agents. 2013 Oct-Dec;27(4):1053-7
pubmed: 24382186
Nat Med. 2012 May 04;18(5):684-92
pubmed: 22561832
Chest. 2002 Dec;122(6):2042-9
pubmed: 12475845
Multidiscip Respir Med. 2014 Nov 19;9(1):58
pubmed: 25699178
Pediatr Allergy Immunol. 2013 Dec;24(8):752-61
pubmed: 24299565
J Allergy Clin Immunol. 2006 Apr;117(4):756-8
pubmed: 16630930
Hum Vaccin Immunother. 2013 Sep;9(9):1849-51
pubmed: 23792443
Front Immunol. 2011 Nov 08;2:54
pubmed: 22566844
Multidiscip Respir Med. 2013 May 22;8(1):33
pubmed: 23692890
Allergy. 2009 Dec;64 Suppl 91:1-59
pubmed: 20041860
Immunol Lett. 2003 Mar 3;86(1):85-91
pubmed: 12600750
World Allergy Organ J. 2010 Aug;3(8 Suppl):S17-23
pubmed: 23282746
J Allergy Clin Immunol. 2011 Jan;127(1 Suppl):S1-55
pubmed: 21122901
APMIS. 2015 Jul;123(7):556-61
pubmed: 26010477
J Biol Regul Homeost Agents. 2011 Jul-Sep;25(3):477-85
pubmed: 22023774