Amide signal intensities may be reduced in the motor cortex and the corticospinal tract of ALS patients.
Amyotrophic lateral sclerosis
Brain
Magnetic resonance imaging
Journal
European radiology
ISSN: 1432-1084
Titre abrégé: Eur Radiol
Pays: Germany
ID NLM: 9114774
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
06
02
2020
accepted:
28
08
2020
revised:
21
07
2020
pubmed:
11
9
2020
medline:
15
4
2021
entrez:
10
9
2020
Statut:
ppublish
Résumé
The aim of the study is to assess amide concentration changes in ALS patients compared with healthy controls by using quantitative amide proton transfer (APT) and multiparameter magnetic resonance imaging, and testing its correlation with clinical scores. Sixteen ALS patients and sixteen healthy controls were recruited as part of the Canadian ALS Neuroimaging Consortium, and multimodal magnetic resonance imaging was performed at 3 T, including APT and diffusion imaging. Lorentz fitting was used to quantify the amide effect. Clinical disability was evaluated using the revised ALS functional rating scale (ALSFRS-R), and its correlation with image characteristics was assessed. The diagnostic performance of different imaging parameters was evaluated with receiver operating characteristic analysis. Our results showed that the amide peak was significantly different between the motor cortex and other gray matter territories within the brain of ALS patients (p < 0.001). Compared with controls, amide signal intensities in ALS were significantly reduced in the motor cortex (p < 0.001) and corticospinal tract (p = 0.046), while abnormalities were not detected using routine imaging methods. There was no significant correlation between amide and ALSFRS-R score. The diagnostic accuracy of the amide peak was superior to that of diffusion imaging. This study demonstrated changes of amide signal intensities in the motor cortex and corticospinal tract of ALS patients. • The neurodegenerative disease amyotrophic lateral sclerosis (ALS) has a lack of objective imaging indicators for diagnosis and assessment. • Analysis of amide proton transfer imaging revealed changes in the motor cortex and corticospinal tract of ALS patients that were not visible on standard magnetic resonance imaging. • The diagnostic accuracy of the amide peak was superior to that of diffusion imaging.
Identifiants
pubmed: 32909054
doi: 10.1007/s00330-020-07243-4
pii: 10.1007/s00330-020-07243-4
doi:
Substances chimiques
Amides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1401-1409Subventions
Organisme : National Natural Science Foundation of China
ID : 81471730
Organisme : National Natural Science Foundation of China
ID : 31870981
Organisme : Natural Science Foundation of Guangdong Province
ID : 2018A030307057
Organisme : Department of Education of Guangdong Province
ID : 2020KZDZX1085
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