Assessment of major mental disorders in a German peripartum cardiomyopathy cohort.
Depression
Mental disorders
Peripartum cardiomyopathy
Journal
ESC heart failure
ISSN: 2055-5822
Titre abrégé: ESC Heart Fail
Pays: England
ID NLM: 101669191
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
revised:
07
07
2020
received:
14
02
2020
accepted:
06
08
2020
pubmed:
11
9
2020
medline:
11
9
2020
entrez:
10
9
2020
Statut:
ppublish
Résumé
Peripartum cardiomyopathy (PPCM) is a heart disease affecting women during the last month of pregnancy or in the first months after delivery. The impact of the disease on mental health is largely unknown. Major mental disorders were assessed by a structured clinical interview in 40 patients with a confirmed PPCM diagnosis, and the data were compared with published prevalence in postpartum women. Circulating biomarkers associated with mental health, such as kynurenine, serotonin, and microRNA (miR)-30e, were evaluated in PPCM and compared with matched healthy pregnancy-matched postpartum controls (PP-Ctrl). Major mental disorders were diagnosed in 65% (26/40) of the PPCM cohort. The prevalence for major depressive disorders was 4-fold, for post-traumatic stress disorder 14-fold, and for panic disorder 6-fold higher in PPCM patients compared with postpartum women without a PPCM diagnosis. Compared with PP-Ctrl, PPCM patients displayed elevated levels of serum kynurenine (P < 0.01), reduced levels of serum serotonin (P < 0.05), and elevated levels of plasma miR-30e (P < 0.05). The majority of PPCM patients in the present cohort displayed mental disorders with a higher prevalence of major depressive disorders, post-traumatic stress disorder (PTBS), and panic disorder, compared with postpartum women without a PPCM diagnosis. This higher prevalence was associated with an impaired tryptophan metabolism and elevated levels of the depression-associated miR-30e, suggesting a potential predisposition for mental disorders at the time of PPCM diagnosis. Consequently, physicians should be aware of the increased risk for mental disorders in PPCM patients, and psychiatric assessment should be included in the diagnosis and management of PPCM patients.
Identifiants
pubmed: 32909398
doi: 10.1002/ehf2.12967
pmc: PMC7754901
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4394-4398Subventions
Organisme : Rebirth Cluster of Excellence (German Research Foundation, Lower Saxony Ministry of Research and Culture)
Organisme : Klinische Forschergruppe (KFO) 311
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : HI-842/11-1
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : HI-842/4-3
Organisme : German Federal Ministry of Education and Research (BMBF)
Informations de copyright
© 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.
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