Diagnostic accuracy of 14-3-3 η protein in rheumatoid arthritis: A meta-analysis.
14-3-3η (14-3-3 eta) protein
diagnostic
meta-analysis
rheumatoid arthritis
Journal
International journal of rheumatic diseases
ISSN: 1756-185X
Titre abrégé: Int J Rheum Dis
Pays: England
ID NLM: 101474930
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
29
05
2020
revised:
18
06
2020
accepted:
05
07
2020
pubmed:
11
9
2020
medline:
16
9
2021
entrez:
10
9
2020
Statut:
ppublish
Résumé
To evaluate the overall diagnostic performance of 14-3-3 η protein in patients with rheumatoid arthritis (RA). PubMed, EMBASE, and Web of Science were searched to acquire eligible studies. Articles published in English before 20 February 2020 were included. Quality Assessment of Diagnostic Accuracy Studies 2 was used to evaluate the risk of bias and application concern of the included articles. Pooled analysis of diagnostic indicators of 14-3-3 η protein for RA was conducted by using a random effects model. Subgroup analysis was used to explore the sources of heterogeneity. Deeks' funnel plot asymmetry test was used to evaluate for the presence of publication bias. A total of 13 studies (1554 positive and 1934 negative participants) were included. The pooled sensitivity and specificity were 0.73 (95% CI 0.71-0.75) and 0.88 (95% CI 0.87-0.90), respectively. The pooled positive/negative likelihood were 5.98 (95% CI 4.39-8.14) and 0.28 (95% CI 0.21-0.37), respectively. In addition, the pooled diagnostic odds ratio was 23.48 (95% CI 13.76-40.08) and the area under curve was 0.9245. The results of subgroup analysis indicated that ethnicity and control group might be the source of heterogeneity. The results of sensitivity analysis were stable. No significant publication bias was found. The current evidence indicated that 14-3-3 η protein has moderate accuracy for the diagnosis of RA.
Identifiants
pubmed: 32909672
doi: 10.1111/1756-185X.13921
pmc: PMC7756802
doi:
Substances chimiques
14-3-3 Proteins
0
Biomarkers
0
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1443-1451Subventions
Organisme : National Natural Science Foundation of China
ID : 81760008
Organisme : National Natural Science Foundation of China
ID : 81460005
Organisme : Guangxi Natural Science Foundation
ID : 2018GXNSFDA281041
Informations de copyright
© 2020 The Authors. International Journal of Rheumatic Diseases published by Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.
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