Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement.
alternative pathway
collectin-12
immunology
infectious disease
inflammation
microbiology
properdin
the complement system
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
10 09 2020
10 09 2020
Historique:
received:
09
07
2020
accepted:
09
09
2020
pubmed:
11
9
2020
medline:
2
3
2021
entrez:
10
9
2020
Statut:
epublish
Résumé
Properdin stabilizes the alternative C3 convertase (C3bBb), whereas its role as pattern-recognition molecule mediating complement activation is disputed for decades. Previously, we have found that soluble collectin-12 (sCL-12) synergizes complement alternative pathway (AP) activation. However, whether this observation is C3 dependent is unknown. By application of the C3-inhibitor Cp40, we found that properdin in normal human serum bound to
Identifiants
pubmed: 32909942
doi: 10.7554/eLife.60908
pii: 60908
pmc: PMC7511233
doi:
pii:
Substances chimiques
Collectins
0
Complement C3
0
Properdin
11016-39-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2020, Zhang et al.
Déclaration de conflit d'intérêts
JZ, LS, DP, AL, GA, TM, YM, PG No competing interests declared, JL inventor of patents (Patent Number: 9630992) and/or patent applications 426 (Application Number: 15/126,937) that describe the use of complement inhibitors for therapeutic purposes, founder of Amyndas Pharmaceuticals, which is developing complement inhibitors (i.e., third-generation compstatins) for clinical applications, and inventor of the compstatin technology licensed to Apellis Pharmaceuticals (i.e., 4[1MeW]7W/POT-4/APL-1 and PEGylated derivatives).
Références
J Immunol. 1989 Jan 1;142(1):202-7
pubmed: 2909614
J Immunol Res. 2019 Jul 29;2019:9164202
pubmed: 31482100
Clin Chem Lab Med. 2014 Mar;52(3):453-61
pubmed: 24114918
J Biol Chem. 2011 Feb 4;286(5):3405-17
pubmed: 21106539
J Exp Med. 1976 Oct 1;144(4):1076-93
pubmed: 978134
Biochim Biophys Acta Gen Subj. 2017 Feb;1861(2):1-14
pubmed: 27864148
J Exp Med. 1958 Oct 1;108(4):515-35
pubmed: 13575682
Infect Immun. 2011 Feb;79(2):724-31
pubmed: 21134964
J Immunol. 2008 Mar 1;180(5):3313-8
pubmed: 18292556
J Biol Chem. 2006 Jan 27;281(4):2128-32
pubmed: 16301317
Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5301-6
pubmed: 24706855
Eur J Biochem. 1994 Feb 1;219(3):759-64
pubmed: 8112326
J Community Hosp Intern Med Perspect. 2015 Feb 03;5(1):26322
pubmed: 25656673
J Biol Chem. 1992 Oct 5;267(28):20435-43
pubmed: 1400362
J Innate Immun. 2013;5(3):242-50
pubmed: 23220946
J Immunol. 2015 Oct 1;195(7):3365-73
pubmed: 26290605
Annu Rev Immunol. 2010;28:131-55
pubmed: 19947883
J Immunol. 2015 Aug 1;195(3):1171-81
pubmed: 26116506
Cell Microbiol. 2012 Jun;14(6):914-36
pubmed: 22309204
Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E534-E539
pubmed: 28069958
J Exp Med. 1975 Oct 1;142(4):856-63
pubmed: 1185108
J Immunol. 2016 Jun 1;196(11):4671-4680
pubmed: 27183616
Mol Immunol. 2000 Jun;37(8):467-78
pubmed: 11090881
J Biol Chem. 2001 Nov 23;276(47):44222-8
pubmed: 11564734
J Immunol. 1993 Sep 1;151(5):2521-8
pubmed: 8360474
Blood. 2014 Mar 27;123(13):2094-101
pubmed: 24497537
Immunol Lett. 2019 Feb;206:28-32
pubmed: 30521839
Front Immunol. 2019 Aug 22;10:2007
pubmed: 31507604
Science. 1954 Aug 20;120(3112):279-85
pubmed: 13186838
J Biol Chem. 2009 Oct 9;284(41):28263-75
pubmed: 19632990
Infect Dis (Lond). 2015 Apr;47(4):203-8
pubmed: 25650730
J Biol Chem. 2005 Jun 17;280(24):22993-9
pubmed: 15845541
J Infect Dis. 2018 Sep 8;218(8):1291-1295
pubmed: 29800140
J Immunol. 2010 Jul 1;185(1):507-16
pubmed: 20530262
Mol Immunol. 2008 Jun;45(11):3278-88
pubmed: 18423602
EMBO J. 2017 Apr 13;36(8):1084-1099
pubmed: 28264884
Biochim Biophys Acta. 2014 Dec;1840(12):3345-56
pubmed: 25199873
J Immunol. 2013 Aug 1;191(3):1324-33
pubmed: 23817411
J Immunol. 2013 Jun 15;190(12):6457-67
pubmed: 23677468
Breast Cancer Res Treat. 2007 Jan;101(2):161-74
pubmed: 16850248
Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9023-8
pubmed: 18579773
J Neurosci Res. 2006 Sep;84(4):874-90
pubmed: 16868960
J Biol Chem. 2011 Feb 18;286(7):5359-67
pubmed: 21135110
Biochem Biophys Res Commun. 2001 Feb 2;280(4):1028-35
pubmed: 11162630
Acta Crystallogr F Struct Biol Commun. 2019 Feb 1;75(Pt 2):0
pubmed: 30713161
J Immunol. 2008 Jun 1;180(11):7613-21
pubmed: 18490764
J Immunol. 2012 Sep 1;189(5):2606-13
pubmed: 22851705
Antioxid Redox Signal. 2013 Jun 10;18(17):2352-63
pubmed: 22900885
J Immunol. 1997 May 1;158(9):4444-51
pubmed: 9127010
J Biol Chem. 2009 Feb 6;284(6):3956-65
pubmed: 19073604
J Exp Med. 1975 Sep 1;142(3):760-72
pubmed: 1165475
Scand J Clin Lab Invest. 2012 Feb;72(1):1-13
pubmed: 22060747
J Biol Chem. 2011 Mar 11;286(10):7822-9
pubmed: 21205820
Sci Rep. 2018 Feb 28;8(1):3821
pubmed: 29491476
J Innate Immun. 2014;6(4):417-25
pubmed: 24355864
Sci Rep. 2017 Mar 20;7:44794
pubmed: 28317919