Early life ionizing radiation exposure and cancer risks: systematic review and meta-analysis.
Cancer
Children
Computed tomography
Ionizing radiation
Postnatal
Prenatal
Radiography
Risk
Journal
Pediatric radiology
ISSN: 1432-1998
Titre abrégé: Pediatr Radiol
Pays: Germany
ID NLM: 0365332
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
23
01
2020
accepted:
05
08
2020
revised:
12
06
2020
pubmed:
11
9
2020
medline:
16
10
2021
entrez:
10
9
2020
Statut:
ppublish
Résumé
Ionizing radiation use for medical diagnostic purposes has substantially increased over the last three decades. Moderate to high doses of radiation are well established causes of cancer, especially for exposure at young ages. However, cancer risk from low-dose medical imaging is debated. To review the literature on cancer risks associated with prenatal and postnatal medical diagnostic ionizing radiation exposure among children and to assess this risk through a meta-analysis. A literature search of five electronic databases supplemented by a hand search was performed to retrieve relevant epidemiological studies published from 2000 to 2019, including patients younger than 22 years of age exposed to medical imaging ionizing radiation. Pooled odds ratio (OR Twenty-four studies were included. For prenatal exposure (radiographs or CT), no significant increased risk was reported for all cancers, leukemia and brain tumors. For postnatal exposure, increased risk was observed only for CT, mostly for leukemia (ERR CT exposure in childhood appears to be associated with increased risk of cancer while no significant association was observed with diagnostic radiographs.
Sections du résumé
BACKGROUND
Ionizing radiation use for medical diagnostic purposes has substantially increased over the last three decades. Moderate to high doses of radiation are well established causes of cancer, especially for exposure at young ages. However, cancer risk from low-dose medical imaging is debated.
OBJECTIVE
To review the literature on cancer risks associated with prenatal and postnatal medical diagnostic ionizing radiation exposure among children and to assess this risk through a meta-analysis.
MATERIALS AND METHODS
A literature search of five electronic databases supplemented by a hand search was performed to retrieve relevant epidemiological studies published from 2000 to 2019, including patients younger than 22 years of age exposed to medical imaging ionizing radiation. Pooled odds ratio (OR
RESULTS
Twenty-four studies were included. For prenatal exposure (radiographs or CT), no significant increased risk was reported for all cancers, leukemia and brain tumors. For postnatal exposure, increased risk was observed only for CT, mostly for leukemia (ERR
CONCLUSION
CT exposure in childhood appears to be associated with increased risk of cancer while no significant association was observed with diagnostic radiographs.
Identifiants
pubmed: 32910229
doi: 10.1007/s00247-020-04803-0
pii: 10.1007/s00247-020-04803-0
doi:
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
45-56Commentaires et corrections
Type : ErratumIn
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