Prevalence of human papillomavirus 6 and 11 variants in recurrent respiratory papillomatosis.
Adolescent
Adult
Female
Genetic Variation
Genotype
Human papillomavirus 11
/ genetics
Human papillomavirus 6
/ genetics
Humans
Laryngeal Neoplasms
/ virology
Male
Papilloma
/ virology
Papillomavirus Infections
/ epidemiology
Prevalence
Respiratory Tract Infections
/ epidemiology
Retrospective Studies
Young Adult
case series
human papillomavirus
recurrent respiratory papillomatosis
risk factors
variants
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
revised:
03
09
2020
received:
11
06
2020
accepted:
08
09
2020
pubmed:
11
9
2020
medline:
9
10
2021
entrez:
10
9
2020
Statut:
ppublish
Résumé
Human papillomavirus (HPV) types 6 and 11 are the etiological agents of recurrent respiratory papillomatosis (RRP). We examined the prevalence and distribution of HPVs 6 and 11 genetic variants in juvenile onset (JORRP) and adult onset (AORRP) laryngeal papillomas. Cases of JORRP and AORRP were collected, retrospectively. HPV detection and genotyping were accessed by polymerase chain reaction-sequencing in 67 RRP samples. Overall, the most prevalent HPV-6 variants were from B1 (55.8%) and B3 (27.9%) sublineages, whereas among HPV-11 positive samples A2 (62.5%) variants were predominant. A higher prevalence of HPV-6 B1 was observed in JORRP (83.3% B1 and 16.7% B3), compared with AORRP cases (58.3% B1 and 41.7% B3). HPV-11 A2 variants were more prevalent both in JORRP (57.2%) and in AORRP cases (70.0%). Nevertheless, with the exception that HPV-6 B1 were significantly less likely to recur, there was a lack of association between any particular HPVs 6 or 11 variant and clinicopathological features. Our data do not support an association between HPVs 6 and 11 variability and RRP.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3835-3840Informations de copyright
© 2020 Wiley Periodicals LLC.
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