Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example.
Journal
American journal of speech-language pathology
ISSN: 1558-9110
Titre abrégé: Am J Speech Lang Pathol
Pays: United States
ID NLM: 9114726
Informations de publication
Date de publication:
12 11 2020
12 11 2020
Historique:
pubmed:
11
9
2020
medline:
25
6
2021
entrez:
10
9
2020
Statut:
ppublish
Résumé
Purpose Diagnosis and classification of primary progressive aphasia (PPA) requires confirmation of specific speech and language symptoms, highlighting the important role of speech-language pathologists in the evaluation process. The purpose of this case report is to inform speech-language pathologists regarding current practices for diagnostic assessment in PPA, describing standard approaches as well as complementary, state-of-the-art procedures that may improve diagnostic precision. Method We describe the diagnostic evaluation of a 49-year-old woman with complaints of progressive word-finding difficulty. She completed standard neurological, neuropsychological, and speech-language evaluations, as well as magnetic resonance and positron emission tomography imaging of her brain. In addition, a history of developmental speech, language, and learning abilities was obtained, as well as genetic testing and assessment of cerebrospinal fluid biomarkers. We discuss the evaluation results in the context of the most current research related to PPA diagnosis. Conclusion Detailed behavioral assessment, thorough intake of symptom history and neurodevelopmental differences, multimodal neuroimaging, and comprehensive examination of genes and biomarkers are of paramount importance for detecting and characterizing PPA, with ramifications for early behavioral and/or pharmacological intervention. Supplemental Material https://doi.org/10.23641/asha.12771113.
Identifiants
pubmed: 32910678
doi: 10.1044/2020_AJSLP-20-00007
pmc: PMC8740567
doi:
Types de publication
Case Reports
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1833-1849Subventions
Organisme : NIA NIH HHS
ID : P30 AG062422
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS050915
Pays : United States
Organisme : NIDCD NIH HHS
ID : K24 DC015544
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG019724
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC016291
Pays : United States
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