Bone marrow involvement: Atypical presentation of early-onset childhood sarcoidosis.
Journal
European journal of rheumatology
ISSN: 2147-9720
Titre abrégé: Eur J Rheumatol
Pays: Turkey
ID NLM: 101656068
Informations de publication
Date de publication:
08 Sep 2020
08 Sep 2020
Historique:
received:
28
04
2020
accepted:
22
06
2020
entrez:
10
9
2020
pubmed:
11
9
2020
medline:
11
9
2020
Statut:
aheadofprint
Résumé
Childhood sarcoidosis is a chronic multisystemic, non-caseating granulomatous disease of unknown etiology. Early-onset disease classically presents with a triad of skin rash, uveitis, and arthritis, but bone marrow involvement is rare. We report a 9-1/2-year old Indian female child who presented with bleeding manifestation, skin rash, uveitis, and arthritis. Bone marrow biopsy showed multiple non-necrotizing granulomas comprising epithelioid cells, mature lymphocytes, and multinucleated giant cells with few eosinophils in the background, with negative staining for acid-fast bacilli or fungi. She was treated successfully with oral prednisolone. This is the first report of an early-onset childhood sarcoidosis with bone marrow involvement from India.
Identifiants
pubmed: 32910768
pii: eurjrheum.2020.20076
doi: 10.5152/eurjrheum.2020.20076
pmc: PMC7574765
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Clin Rheumatol. 2016 Jul;35(7):1879-84
pubmed: 25616361
Indian J Dermatol Venereol Leprol. 2016 Sep-Oct;82(5):542-5
pubmed: 27297270
Diagnostics (Basel). 2019 Oct 25;9(4):
pubmed: 31731423
J Clin Diagn Res. 2017 Aug;11(8):WD01-WD03
pubmed: 28969254
Expert Rev Respir Med. 2008 Apr;2(2):139-43
pubmed: 20477242
Medicine (Baltimore). 2018 Jan;97(4):e9726
pubmed: 29369209
Am Fam Physician. 2016 May 15;93(10):840-8
pubmed: 27175719
Haematologia (Budap). 2002;32(4):419-25
pubmed: 12803116
Hematol Pathol. 1988;2(1):43-50
pubmed: 3069830
Clin Exp Rheumatol. 2002 Mar-Apr;20(2):231-7
pubmed: 12051406
BMJ Case Rep. 2011 Dec 20;2011:
pubmed: 22669984
J Community Hosp Intern Med Perspect. 2019 Apr 12;9(2):150-154
pubmed: 31061693
World J Pediatr. 2011 May;7(2):103-10
pubmed: 21574025
J Nat Sci Biol Med. 2012 Jan;3(1):87-9
pubmed: 22690059
Pediatr Rheumatol Online J. 2008 Sep 23;6:16
pubmed: 18811966
Indian Pediatr. 2019 Jan 15;56(1):37-40
pubmed: 30806359
Sarcoidosis Vasc Diffuse Lung Dis. 2003 Mar;20(1):46-52
pubmed: 12737280
Eur J Intern Med. 2013 Jul;24(5):468-73
pubmed: 23414770
Acta Paediatr. 2004 Jan;93(1):30-6
pubmed: 14989436
J Med Case Rep. 2009 Jul 29;3:8573
pubmed: 19830230
Biomark Res. 2016 Sep 15;4:18
pubmed: 27651903