IgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcusaureus.
Adaptive Immunity
/ immunology
Allergens
/ immunology
Animals
Female
Hypersensitivity
/ immunology
Immunoglobulin E
/ immunology
Mast Cells
/ immunology
Mice
Mice, Inbred C57BL
Skin
/ immunology
Staphylococcal Infections
/ immunology
Staphylococcal Skin Infections
/ immunology
Staphylococcus aureus
/ immunology
IgE
Staphylococcus aureus
allergy
allergy module
bacteria
basophils
degranulation
host defense
mast cells
type 2 immunity
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
13 10 2020
13 10 2020
Historique:
received:
21
10
2019
revised:
02
06
2020
accepted:
06
08
2020
pubmed:
11
9
2020
medline:
20
4
2021
entrez:
10
9
2020
Statut:
ppublish
Résumé
Allergies are considered to represent mal-directed type 2 immune responses against mostly innocuous exogenous compounds. Immunoglobulin E (IgE) antibodies are a characteristic feature of allergies and mediate hypersensitivity against allergens through activation of effector cells, particularly mast cells (MCs). Although the physiological functions of this dangerous branch of immunity have remained enigmatic, recent evidence shows that allergic immune reactions can help to protect against the toxicity of venoms. Because bacteria are a potent alternative source of toxins, we assessed the possible role of allergy-like type 2 immunity in antibacterial host defense. We discovered that the adaptive immune response against Staphylococcus aureus (SA) skin infection substantially improved systemic host defense against secondary SA infections in mice. Moreover, this acquired protection depended on IgE effector mechanisms and MCs. Importantly, our results reveal a previously unknown physiological function of allergic immune responses, IgE antibodies, and MCs in host defense against a pathogenic bacterium.
Identifiants
pubmed: 32910906
pii: S1074-7613(20)30335-6
doi: 10.1016/j.immuni.2020.08.002
pmc: PMC7572876
mid: NIHMS1627765
pii:
doi:
Substances chimiques
Allergens
0
Immunoglobulin E
37341-29-0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
793-804.e9Subventions
Organisme : NIAID NIH HHS
ID : R01 AI132494
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI023990
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR067145
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI070813
Pays : United States
Organisme : Austrian Science Fund FWF
ID : P 31113
Pays : Austria
Commentaires et corrections
Type : CommentIn
Type : ErratumIn
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
Références
Immunol Rev. 2015 Nov;268(1):25-51
pubmed: 26497511
Nat Med. 2011 Sep 18;17(10):1310-4
pubmed: 21926978
Am J Respir Crit Care Med. 2010 Apr 15;181(8):782-7
pubmed: 20382801
Cell. 2014 Jun 5;157(6):1309-1323
pubmed: 24906149
Immunity. 2019 Mar 19;50(3):552-565
pubmed: 30893586
Immunity. 2015 Jul 21;43(1):29-40
pubmed: 26200011
J Leukoc Biol. 2006 Oct;80(4):816-26
pubmed: 16864603
Eur J Immunol. 2019 Sep;49(9):1334-1343
pubmed: 31355918
Eur Respir J. 2019 Sep 12;54(3):
pubmed: 31285304
Virulence. 2018 Jan 1;9(1):231-247
pubmed: 29099326
Microb Pathog. 2013 Oct;63:24-9
pubmed: 23747685
Q Rev Biol. 1991 Mar;66(1):23-62
pubmed: 2052671
J Clin Invest. 2016 Dec 1;126(12):4497-4515
pubmed: 27820702
BMC Bioinformatics. 2009 Feb 03;10:48
pubmed: 19192299
Pharmacol Ther. 2018 Nov;191:50-64
pubmed: 29909239
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Immunol Rev. 2018 Mar;282(1):188-197
pubmed: 29431211
Clin Infect Dis. 2008 Jun 1;46 Suppl 5:S368-77
pubmed: 18462092
J Allergy Clin Immunol. 2017 Aug;140(2):335-348
pubmed: 28780941
J Immunol. 2008 Apr 1;180(7):4742-53
pubmed: 18354198
Nat Immunol. 2011 Jun;12(6):527-35
pubmed: 21552267
Immunol Rev. 2018 Mar;282(1):87-113
pubmed: 29431205
Allergy Asthma Immunol Res. 2019 Sep;11(5):593-603
pubmed: 31332972
Sci Rep. 2017 Dec 4;7(1):16878
pubmed: 29203879
Sci Immunol. 2018 Jul 6;3(25):
pubmed: 29980619
Nat Rev Immunol. 2014 Jul;14(7):478-94
pubmed: 24903914
J Clin Invest. 2011 Oct;121(10):4180-91
pubmed: 21926462
Curr Opin Microbiol. 2015 Feb;23:42-8
pubmed: 25461571
Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2272-2274
pubmed: 29476009
Nat Rev Immunol. 2013 May;13(5):362-75
pubmed: 23558889
Cell. 1994 Feb 11;76(3):519-29
pubmed: 8313472
Mol Cell Proteomics. 2005 Dec;4(12):2010-21
pubmed: 16249172
Nat Rev Immunol. 2020 Oct;20(10):603-614
pubmed: 32367051
Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14337-42
pubmed: 26489655
J Allergy Clin Immunol. 2016 Jun;137(6):1631-1645
pubmed: 27263999
J Allergy Clin Immunol. 2016 Jan;137(1):246-257.e11
pubmed: 26410782
Immunity. 2013 Nov 14;39(5):976-85
pubmed: 24210353
Infect Immun. 2013 Apr;81(4):1306-15
pubmed: 23381997
N Engl J Med. 2014 Oct 23;371(17):1619-28
pubmed: 25337751
Nat Protoc. 2018 Mar;13(3):530-550
pubmed: 29446774
Nucleic Acids Res. 2019 Jan 8;47(D1):D442-D450
pubmed: 30395289
Curr Opin Microbiol. 2014 Feb;17:32-7
pubmed: 24581690
J Allergy Clin Immunol. 2004 Oct;114(4):981-3
pubmed: 15480349
Immunity. 2018 Feb 20;48(2):396
pubmed: 29466760
J Immunol. 1980 Jun;124(6):2728-37
pubmed: 7373045
Nat Med. 2012 May 04;18(5):693-704
pubmed: 22561833
Transgenic Res. 2008 Apr;17(2):307-15
pubmed: 17972156
Front Immunol. 2018 Jul 09;9:1532
pubmed: 30038613
Lancet Infect Dis. 2019 Jan;19(1):56-66
pubmed: 30409683
Immunol Rev. 2018 Mar;282(1):121-150
pubmed: 29431212
Cell. 1993 Dec 3;75(5):969-76
pubmed: 8252632
Nature. 1994 Aug 4;370(6488):367-70
pubmed: 8047141
Mol Syst Biol. 2014 Oct 30;10:757
pubmed: 25358341
PLoS One. 2010 Dec 02;5(12):e14210
pubmed: 21151984
Immunity. 2013 Nov 14;39(5):963-75
pubmed: 24210352
Lancet. 2006 Mar 4;367(9512):731-9
pubmed: 16517273
Semin Immunopathol. 2016 Sep;38(5):581-603
pubmed: 27225312
Nature. 2013 Nov 21;503(7476):397-401
pubmed: 24172897
Sci Adv. 2019 Jan 02;5(1):eaav0216
pubmed: 30613778
Nat Rev Immunol. 2016 Aug;16(8):524-32
pubmed: 27396446
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2013 May;56(5-6):698-706
pubmed: 23703488
J Allergy Clin Immunol. 2017 Feb;139(2):492-500.e8
pubmed: 27315768
MAbs. 2016 Oct;8(7):1347-1360
pubmed: 27467113
J Exp Med. 2007 Oct 29;204(11):2629-39
pubmed: 17923505
Nature. 2012 Apr 25;484(7395):465-72
pubmed: 22538607
PLoS Pathog. 2017 Sep 21;13(9):e1006452
pubmed: 28934339
Cell Host Microbe. 2019 Jul 10;26(1):114-122.e8
pubmed: 31278040
Allergy. 2017 May;72(5):754-763
pubmed: 27753449
Science. 2019 Aug 30;365(6456):
pubmed: 31371561
Science. 2006 Jul 28;313(5786):526-30
pubmed: 16873664