New drug approvals for 2019: Synthesis and clinical applications.
Chemical synthesis
Clinical applications
New drugs
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
01 Nov 2020
01 Nov 2020
Historique:
received:
02
07
2020
revised:
13
07
2020
accepted:
13
07
2020
pubmed:
11
9
2020
medline:
20
4
2021
entrez:
10
9
2020
Statut:
ppublish
Résumé
48 new drugs including 38 chemical entities (33 new chemical entities, 3 new diagnostic agents, and 2 payloads of antibody drug conjugates) and 10 biologics were approved by the U.S. Food and Drug Administration (FDA) during 2019. These marketed new drugs represent privileged structures and novel action of mechanism, and thus can be served as leads to discover new drugs with the similar biological targets and improved therapeutic efficacy. This review aims to provide an overview regarding the synthetic approaches of 33 new chemical entities approved by the FDA in 2019 and their clinical applications.
Identifiants
pubmed: 32911308
pii: S0223-5234(20)30639-5
doi: 10.1016/j.ejmech.2020.112667
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
112667Informations de copyright
Copyright © 2020 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.