The transcriptional factors CDX2 and FOXA1 in chordomas.
Chondrosacroma
Chordoma
Differential diagnosis
Endoderm
Immunohistochemistry
Mesoderm
Notochord
Journal
Pathology, research and practice
ISSN: 1618-0631
Titre abrégé: Pathol Res Pract
Pays: Germany
ID NLM: 7806109
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
08
07
2020
revised:
02
08
2020
accepted:
04
08
2020
pubmed:
11
9
2020
medline:
26
8
2021
entrez:
10
9
2020
Statut:
ppublish
Résumé
Chordomas are rare osseous tumors believed to originate from notochordal remnants through brachyury activation. CDX2 and FOXA1 are both induced by brachyury, but their expression has not been studied in chordomas. We retrospectively studied the immunohistochemical expression of these two factors in 57 chordomas, finding that CDX2 is not expressed in these tumors. FOXA1 expression was found in 7 (12.3%) tumors. No association of FOXA1 expression with clinical factors was found. Thus, CDX2 expression is not a feature of chordomas, while a limited expression of FOXA1 is seen.
Identifiants
pubmed: 32911347
pii: S0344-0338(20)32015-X
doi: 10.1016/j.prp.2020.153160
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
CDX2 Transcription Factor
0
CDX2 protein, human
0
FOXA1 protein, human
0
Hepatocyte Nuclear Factor 3-alpha
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
153160Informations de copyright
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