Structural basis for sequestration and autoinhibition of cGAS by chromatin.
Amino Acid Sequence
Animals
Autoantigens
/ chemistry
Binding Sites
Binding, Competitive
Catalytic Domain
Chromatin
/ chemistry
Cryoelectron Microscopy
DNA
/ chemistry
Enzyme Activation
Histones
/ chemistry
Humans
Hydrophobic and Hydrophilic Interactions
Immunity, Innate
Mice
Models, Molecular
Nucleosomes
/ chemistry
Nucleotidyltransferases
/ antagonists & inhibitors
Protein Multimerization
THP-1 Cells
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
13
05
2020
accepted:
24
08
2020
pubmed:
11
9
2020
medline:
20
3
2021
entrez:
10
9
2020
Statut:
ppublish
Résumé
Cyclic GMP-AMP synthase (cGAS) is an innate immune sensor for cytosolic microbial DNA
Identifiants
pubmed: 32911480
doi: 10.1038/s41586-020-2748-0
pii: 10.1038/s41586-020-2748-0
doi:
Substances chimiques
Autoantigens
0
Chromatin
0
Histones
0
Nucleosomes
0
DNA
9007-49-2
Nucleotidyltransferases
EC 2.7.7.-
cGAS protein, human
EC 2.7.7.-
cGAS protein, mouse
EC 2.7.7.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
678-682Références
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